Document Detail

Organization of central hyperthermic mechanisms in helium-cold hypothermic hamsters.
MedLine Citation:
PMID:  3463374     Owner:  NLM     Status:  MEDLINE    
We have investigated the ability of three hyperthermic stimuli (PGE2, 5-HT and ACh) to elicit hyperthermia in the Helium-Cold (He-Cold) hypothermic hamster. Hamsters in these conditions are poikilothermic and will passively follow room temperature in a regulated cold room. Animals were injected centrally at AH/POA sites via an indwelling guide tube at body temperatures maintained between 9-12 degrees C. Active sites in the AH/POA were determined prior to the experiment by PGE2 injection. PGE2 injection at an effective AH/POA site immediately reversed the anesthetic induced hypothermia in warm air. Hamsters were induced into hypothermia by the He-Cold induction method and body temperatures were maintained in a 9 degrees C cold room. Colonic temperatures were monitored at 5 minute intervals by a YSI thermistor probe and telethermometer. Central injections of 5-HT (2 micrograms/microliter) and ACh (50 micrograms/microliter) at effective AH/POA sites evoked significant increases in colonic temperature in He-Cold hamsters. PGE2 injections were not different from saline control injections and did not elicit pronounced temperature changes in these animals. Specific blockade of the 5-HT and ACh temperature increases was demonstrated with specific antagonist injections. The results suggest that the central organization of heat-gain mechanisms in the AH/POA is the same as normothermic animals even at temperatures well below those previously investigated.
C W Simpson; G E Resch
Related Documents :
8781864 - Effect of posture on body temperature of young men in cold air.
11914384 - Cardiorespiratory responses of the common carp (cyprinus carpio) to severe hypoxia at t...
2106564 - A rapid cold-hardening response protecting against cold shock injury in drosophila mela...
7397594 - The effects of cold stress on neonatal calves. i. clinical condition and pathological l...
2955124 - Cytochemical localization of ca2+-atpase activity in the guinea pig sympathetic ganglia.
24141484 - Groundwater levels time series sensitivity to pluviometry and air temperature: a geosta...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  17     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-11-04     Completed Date:  1986-11-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcholine / antagonists & inhibitors,  pharmacology
Atropine / pharmacology
Body Temperature / drug effects
Cold Temperature
Fever / chemically induced,  etiology,  physiopathology*
Hypothalamus / physiopathology*
Ketamine / pharmacology
Prostaglandins E / pharmacology
Serotonin / pharmacology
Serotonin Antagonists / pharmacology
Reg. No./Substance:
0/Prostaglandins E; 0/Serotonin Antagonists; 363-24-6/Dinoprostone; 50-67-9/Serotonin; 51-55-8/Atropine; 51-84-3/Acetylcholine; 6740-88-1/Ketamine; 7440-59-7/Helium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The use of CA-50 radioimmunoassay inhibition test in the differential diagnosis of benign and malign...
Next Document:  Involvement of intramural prostaglandin E2 in prenatal patency of the lamb ductus arteriosus.