Document Detail


Organization of central hyperthermic mechanisms in helium-cold hypothermic hamsters.
MedLine Citation:
PMID:  3463374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have investigated the ability of three hyperthermic stimuli (PGE2, 5-HT and ACh) to elicit hyperthermia in the Helium-Cold (He-Cold) hypothermic hamster. Hamsters in these conditions are poikilothermic and will passively follow room temperature in a regulated cold room. Animals were injected centrally at AH/POA sites via an indwelling guide tube at body temperatures maintained between 9-12 degrees C. Active sites in the AH/POA were determined prior to the experiment by PGE2 injection. PGE2 injection at an effective AH/POA site immediately reversed the anesthetic induced hypothermia in warm air. Hamsters were induced into hypothermia by the He-Cold induction method and body temperatures were maintained in a 9 degrees C cold room. Colonic temperatures were monitored at 5 minute intervals by a YSI thermistor probe and telethermometer. Central injections of 5-HT (2 micrograms/microliter) and ACh (50 micrograms/microliter) at effective AH/POA sites evoked significant increases in colonic temperature in He-Cold hamsters. PGE2 injections were not different from saline control injections and did not elicit pronounced temperature changes in these animals. Specific blockade of the 5-HT and ACh temperature increases was demonstrated with specific antagonist injections. The results suggest that the central organization of heat-gain mechanisms in the AH/POA is the same as normothermic animals even at temperatures well below those previously investigated.
Authors:
C W Simpson; G E Resch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  17     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-11-04     Completed Date:  1986-11-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / antagonists & inhibitors,  pharmacology
Animals
Atropine / pharmacology
Biomechanics
Body Temperature / drug effects
Cold Temperature
Cricetinae
Dinoprostone
Female
Fever / chemically induced,  etiology,  physiopathology*
Helium
Hypothalamus / physiopathology*
Injections
Ketamine / pharmacology
Male
Mesocricetus
Prostaglandins E / pharmacology
Serotonin / pharmacology
Serotonin Antagonists / pharmacology
Chemical
Reg. No./Substance:
0/Prostaglandins E; 0/Serotonin Antagonists; 363-24-6/Dinoprostone; 50-67-9/Serotonin; 51-55-8/Atropine; 51-84-3/Acetylcholine; 6740-88-1/Ketamine; 7440-59-7/Helium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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