| Organization of central hyperthermic mechanisms in helium-cold hypothermic hamsters. | |
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MedLine Citation:
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PMID: 3463374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated the ability of three hyperthermic stimuli (PGE2, 5-HT and ACh) to elicit hyperthermia in the Helium-Cold (He-Cold) hypothermic hamster. Hamsters in these conditions are poikilothermic and will passively follow room temperature in a regulated cold room. Animals were injected centrally at AH/POA sites via an indwelling guide tube at body temperatures maintained between 9-12 degrees C. Active sites in the AH/POA were determined prior to the experiment by PGE2 injection. PGE2 injection at an effective AH/POA site immediately reversed the anesthetic induced hypothermia in warm air. Hamsters were induced into hypothermia by the He-Cold induction method and body temperatures were maintained in a 9 degrees C cold room. Colonic temperatures were monitored at 5 minute intervals by a YSI thermistor probe and telethermometer. Central injections of 5-HT (2 micrograms/microliter) and ACh (50 micrograms/microliter) at effective AH/POA sites evoked significant increases in colonic temperature in He-Cold hamsters. PGE2 injections were not different from saline control injections and did not elicit pronounced temperature changes in these animals. Specific blockade of the 5-HT and ACh temperature increases was demonstrated with specific antagonist injections. The results suggest that the central organization of heat-gain mechanisms in the AH/POA is the same as normothermic animals even at temperatures well below those previously investigated. |
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Authors:
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C W Simpson; G E Resch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research bulletin Volume: 17 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-11-04 Completed Date: 1986-11-04 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 117-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
/
antagonists & inhibitors,
pharmacology Animals Atropine / pharmacology Biomechanics Body Temperature / drug effects Cold Temperature Cricetinae Dinoprostone Female Fever / chemically induced, etiology, physiopathology* Helium Hypothalamus / physiopathology* Injections Ketamine / pharmacology Male Mesocricetus Prostaglandins E / pharmacology Serotonin / pharmacology Serotonin Antagonists / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 0/Serotonin Antagonists; 363-24-6/Dinoprostone; 50-67-9/Serotonin; 51-55-8/Atropine; 51-84-3/Acetylcholine; 6740-88-1/Ketamine; 7440-59-7/Helium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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