Document Detail


Organization, barrier function and antimicrobial lipids of the oral mucosa.
MedLine Citation:
PMID:  23320785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As one moves from the skin across the vermilion region of the lip and into the oral cavity, the oral mucosa is encountered. The oral mucosa consists of connective tissue known as the lamina propria covered by a stratified squamous epithelium. In the regions of the hard palate and gingiva, the epithelium is keratinized like the epidermis. In the buccal region, the floor of the mouth and the underside of the tongue, the epithelium is non-keratinized. The epithelium on the dorsum of the tongue is a specialized epithelium, but can be approximated as a mosaic of keratinized and non-keratinized epithelia. The non-keratinized epithelial regions do not produce a stratum corneum. Nuclei with intact DNA are retained in the superficial cells. In all regions, the outer portions of the epithelium provide a protective permeability barrier, which varies regionally. Antimicrobial lipids at the surfaces of the oral mucosa are an integral part of innate immunity.
Authors:
D V Dawson; D R Drake; J R Hill; K A Brogden; C L Fischer; P W Wertz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-02-09
Journal Detail:
Title:  International journal of cosmetic science     Volume:  35     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-16     Completed Date:  2013-12-10     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  220-3     Citation Subset:  IM    
Copyright Information:
© 2013 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
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MeSH Terms
Descriptor/Qualifier:
Epithelium / physiology
Humans
Lipids / physiology*
Mouth Mucosa / physiology*
Grant Support
ID/Acronym/Agency:
R01 DE014390/DE/NIDCR NIH HHS; R01 DE018032/DE/NIDCR NIH HHS; R01 DE018032/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Lipids
Comments/Corrections

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