Document Detail

Organisation of collagen fibrils in tendon: changes induced by an anabolic steroid. I. Functional and ultrastructural studies.
MedLine Citation:
PMID:  2881396     Owner:  NLM     Status:  MEDLINE    
The organisation of tendon collagen fibrils has been studied by electron microscopy after treatment with an anabolic steroid hormone in a short-term and a long-term study. The effect of anabolic steroids is of interest because of their use in competitive sports and in clinical therapy. In a functional experimental model the unexpected occurrence of dysplastic as well as ruptured and dissociated collagen fibrils was revealed. The striking time-dependent collagen dysplasia and other pathological findings strongly suggest that in mice anabolic steroid treatment predisposes to tendon rupture especially when the animals are exercised. The possible underlying mode of action of anabolic steroid hormone on connective tissue is discussed.
H Michna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. B, Cell pathology including molecular pathology     Volume:  52     ISSN:  0340-6075     ISO Abbreviation:  Virchows Arch., B, Cell Pathol.     Publication Date:  1986  
Date Detail:
Created Date:  1987-03-31     Completed Date:  1987-03-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9316922     Medline TA:  Virchows Arch B Cell Pathol Incl Mol Pathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  75-86     Citation Subset:  IM    
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MeSH Terms
Anabolic Agents / pharmacology*
Collagen / metabolism*
Mice, Inbred Strains
Microscopy, Electron
Tendons / metabolism*,  ultrastructure
Reg. No./Substance:
0/Anabolic Agents; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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