| Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy. | |
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MedLine Citation:
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PMID: 17288423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report energy-transferring organically modified silica nanoparticles for two-photon photodynamic therapy. These nanoparticles co-encapsulate two-photon fluorescent dye nanoaggregates as an energy up-converting donor and a photosensitizing PDT drug as an acceptor. They combine two features: (i) aggregation-enhanced two-photon absorption and emission properties of a novel two-photon dye and (ii) nanoscopic fluorescence resonance energy transfer between this nanoaggregate and a photosensitizer, 2-devinyl-2-(1-hexyloxyethyl)pyropheophorbide. Stable aqueous dispersions of the co-encapsulating nanoparticles (diameter < or = 30 nm) have been prepared in the nonpolar interior of micelles by coprecipitating an organically modified silica sol with the photosensitizer and an excess amount of the two-photon dye which forms fluorescent aggregates by phase separation from the particle matrix. Using a multidisciplinary nanophotonic approach, we show: (i) indirect excitation of the photosensitizer through efficient two-photon excited intraparticle energy transfer from the dye aggregates in the intracellular environment of tumor cells and (ii) generation of singlet oxygen and in vitro cytotoxic effect in tumor cells by photosensitization under two-photon irradiation. |
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Authors:
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Sehoon Kim; Tymish Y Ohulchanskyy; Haridas E Pudavar; Ravindra K Pandey; Paras N Prasad |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-02-09 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 129 ISSN: 0002-7863 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-28 Completed Date: 2007-06-01 Revised Date: 2013-04-12 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 2669-75 Citation Subset: IM |
Affiliation:
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Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY 14260-3000, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Antineoplastic Agents / chemistry*, pharmacology Chemical Precipitation Chlorophyll / analogs & derivatives, chemistry, pharmacology Fluorescent Dyes / chemistry* HeLa Cells / drug effects, pathology Humans Intracellular Space / pathology Micelles Nanoparticles / chemistry* Photochemotherapy* Photons* Photosensitizing Agents / chemistry*, pharmacology Singlet Oxygen / chemistry Spectrometry, Fluorescence |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA 119358-01/CA/NCI NIH HHS; R01 CA119358-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Fluorescent Dyes; 0/Micelles; 0/Photosensitizing Agents; 1406-65-1/Chlorophyll; 149402-51-7/2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a; 17778-80-2/Singlet Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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