Document Detail

Organically modified silica nanoparticles co-encapsulating photosensitizing drug and aggregation-enhanced two-photon absorbing fluorescent dye aggregates for two-photon photodynamic therapy.
MedLine Citation:
PMID:  17288423     Owner:  NLM     Status:  MEDLINE    
We report energy-transferring organically modified silica nanoparticles for two-photon photodynamic therapy. These nanoparticles co-encapsulate two-photon fluorescent dye nanoaggregates as an energy up-converting donor and a photosensitizing PDT drug as an acceptor. They combine two features: (i) aggregation-enhanced two-photon absorption and emission properties of a novel two-photon dye and (ii) nanoscopic fluorescence resonance energy transfer between this nanoaggregate and a photosensitizer, 2-devinyl-2-(1-hexyloxyethyl)pyropheophorbide. Stable aqueous dispersions of the co-encapsulating nanoparticles (diameter < or = 30 nm) have been prepared in the nonpolar interior of micelles by coprecipitating an organically modified silica sol with the photosensitizer and an excess amount of the two-photon dye which forms fluorescent aggregates by phase separation from the particle matrix. Using a multidisciplinary nanophotonic approach, we show: (i) indirect excitation of the photosensitizer through efficient two-photon excited intraparticle energy transfer from the dye aggregates in the intracellular environment of tumor cells and (ii) generation of singlet oxygen and in vitro cytotoxic effect in tumor cells by photosensitization under two-photon irradiation.
Sehoon Kim; Tymish Y Ohulchanskyy; Haridas E Pudavar; Ravindra K Pandey; Paras N Prasad
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-02-09
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  129     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-28     Completed Date:  2007-06-01     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2669-75     Citation Subset:  IM    
Institute for Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY 14260-3000, USA.
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MeSH Terms
Antineoplastic Agents / chemistry*,  pharmacology
Chemical Precipitation
Chlorophyll / analogs & derivatives,  chemistry,  pharmacology
Fluorescent Dyes / chemistry*
HeLa Cells / drug effects,  pathology
Intracellular Space / pathology
Nanoparticles / chemistry*
Photosensitizing Agents / chemistry*,  pharmacology
Singlet Oxygen / chemistry
Spectrometry, Fluorescence
Grant Support
R01 CA 119358-01/CA/NCI NIH HHS; R01 CA119358-01/CA/NCI NIH HHS
Reg. No./Substance:
0/Antineoplastic Agents; 0/Fluorescent Dyes; 0/Micelles; 0/Photosensitizing Agents; 1406-65-1/Chlorophyll; 149402-51-7/2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a; 17778-80-2/Singlet Oxygen

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