Document Detail

Organic neurotoxins in seafoods.
MedLine Citation:
PMID:  7656483     Owner:  NLM     Status:  MEDLINE    
Toxins formed by organic micro-organisms may accumulate within certain tissues of predacious sea animals, which may serve as a source of seafood poisoning for the higher food chain. Such toxins are distinct from inorganic chemicals or infectious agents which may have contaminated the seafoods. Distinct clinical syndromes have emerged, and the individual toxins have been identified. Clinical manifestations of each begin with a gastrointestinal prodrome and headache, followed by sensorimotor deficits. Bulbar and cognitive changes are associated with the more lethal tetrodotoxin, saxitoxin, and domoic acid toxin. Tetrodotoxin and saxitoxin block sodium channels, while ciguatoxin opens them. Domoic acid stimulates excitatory amino acids at the NMDA receptors.
M R Watters
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  97     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-05     Completed Date:  1995-10-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  119-24     Citation Subset:  IM    
University of Hawaii, Neurology Service, Tripler Army Medical Center, Honolulu 96859, USA.
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MeSH Terms
Brain Diseases / etiology
Bulbar Palsy, Progressive / etiology
Ciguatoxins / adverse effects,  pharmacology*
Cognition Disorders / etiology
Foodborne Diseases* / drug therapy
Gastrointestinal Diseases / etiology
Headache / etiology
Mannitol / therapeutic use
Psychomotor Disorders / etiology
Receptors, N-Methyl-D-Aspartate / drug effects
Saxitoxin / adverse effects*,  pharmacology
Sodium Channels / drug effects
Tetrodotoxin / adverse effects*,  pharmacology
Reg. No./Substance:
0/Receptors, N-Methyl-D-Aspartate; 0/Sodium Channels; 11050-21-8/Ciguatoxins; 35523-89-8/Saxitoxin; 4368-28-9/Tetrodotoxin; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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