Document Detail

Organic bases of depression in the elderly.
MedLine Citation:
PMID:  2035971     Owner:  NLM     Status:  MEDLINE    
Early studies suggested that cerebrovascular change may be an etiological factor in the development of late-life depression. With the advent of magnetic resonance imaging (MRI), it has become possible to examine this hypothesis. MRI studies have demonstrated that patients with late-onset depression have more severe and frequent patchy lesions in the frontal deep white matter and basal ganglia than do controls or patients with early-onset depression. Patients with basal ganglia lesions, primarily caudate, are more likely to develop delirium with antidepressants and electroshock treatment (EST). The prognostic significance and the relationship of these lesions to cognitive impairment is unclear.
K R Krishnan
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of medicine     Volume:  42     ISSN:  0066-4219     ISO Abbreviation:  Annu. Rev. Med.     Publication Date:  1991  
Date Detail:
Created Date:  1991-06-26     Completed Date:  1991-06-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985151R     Medline TA:  Annu Rev Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710.
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MeSH Terms
Brain Diseases / complications*,  diagnosis
Depression / etiology*
Leukoencephalopathy, Progressive Multifocal / complications
Magnetic Resonance Imaging
Grant Support

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