Document Detail

Organic anions induce colinic secretion.
MedLine Citation:
PMID:  5886     Owner:  NLM     Status:  MEDLINE    
Experiments were conducted by instilling test solutions into the cleaned colon of anesthetized rats. Isotonic test solutions at an acid (2.9% or neutral (7.0) pH and containing acetic acid or acetate ions were used. At the lower pH, acetic acid was absorbed well absorbed and the colon absorbed fluid. The secretory effect could not be reproduced by hydrochloric acid solutions at pH 2.9. Fluid secretion induced by acetic acid was associated with discharge of mucus from goblet cells. The interference of colonic absorption by acetic acid might be important in some diarrheal diseases.
L Bustos-Fernández; E González; L L de Paolo; C D Celener; K O de Furuya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of digestive diseases     Volume:  21     ISSN:  0002-9211     ISO Abbreviation:  Am J Dig Dis     Publication Date:  1976 Apr 
Date Detail:
Created Date:  1976-08-02     Completed Date:  1976-08-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404011     Medline TA:  Am J Dig Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  329-32     Citation Subset:  AIM; IM    
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MeSH Terms
Acetic Acids / analysis,  pharmacology*
Colon / secretion*
Hydrogen-Ion Concentration
Intestinal Mucosa / anatomy & histology,  secretion*
Potassium / analysis
Sodium / analysis
Water-Electrolyte Balance / drug effects*
Reg. No./Substance:
0/Acetic Acids; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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