| Organic anion-transporting polypeptides at the blood-brain and blood-cerebrospinal fluid barriers. | |
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MedLine Citation:
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PMID: 17950374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organic anion-transporting polypeptides (Oatps) are solute carrier family members that exhibit marked evolutionary conservation. Mammalian Oatps exhibit wide tissue expression with an emphasis on expression in barrier cells. In the brain, Oatps are expressed in the blood-brain barrier endothelial cells and blood-cerebrospinal fluid barrier epithelial cells. This expression profile serves to illustrate a central role for Oatps in transporting endo- and xenobiotics across brain barrier cells. This chapter will detail the expression patterns and substrate specificities of Oatps expressed in the brain, and will place special emphases on the role of Oatps in prostaglandin synthesis and in the transport of conjugated endobiotics. |
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Authors:
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Daniel E Westholm; Jon N Rumbley; David R Salo; Timothy P Rich; Grant W Anderson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current topics in developmental biology Volume: 80 ISSN: 0070-2153 ISO Abbreviation: Curr. Top. Dev. Biol. Publication Date: 2008 |
Date Detail:
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Created Date: 2007-10-22 Completed Date: 2007-11-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0163114 Medline TA: Curr Top Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 135-70 Citation Subset: IM |
Affiliation:
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College of Pharmacy, University of Minnesota, Duluth, Minnesota 55812, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Blood-Brain Barrier / physiology* Dehydroepiandrosterone / metabolism Estradiol / metabolism Female Humans Male Models, Molecular Models, Neurological Molecular Sequence Data Organic Anion Transporters / cerebrospinal fluid, chemistry, genetics, metabolism* Prostaglandins / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK054060/DK/NIDDK NIH HHS; T32HL07741/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Organic Anion Transporters; 0/Prostaglandins; 50-28-2/Estradiol; 53-43-0/Dehydroepiandrosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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