Document Detail

Organic acids influence iron uptake in the human epithelial cell line Caco-2.
MedLine Citation:
PMID:  12358508     Owner:  NLM     Status:  MEDLINE    
It has previously been suggested that organic acids enhance iron absorption. We have studied the effect of nine organic acids on the absorption of Fe(II) and Fe(III) in the human epithelial cell line Caco-2. The effect obtained was dose-dependent, and the greatest increase (43-fold) was observed for tartaric acid (4 mmol/L) on Fe(III) (10 micromol/L). Tartaric, malic, succinic, and fumaric acids enhanced Fe(II) and Fe(III) uptake. Citric and oxalic acid, on the other hand, inhibited Fe(II) uptake but enhanced Fe(III) uptake. Propionic and acetic acid increased the Fe(II) uptake, but had no effect on Fe(III) uptake. Our results show a correlation between absorption pattern and chemical structure; e.g. hydroxyl groups, in addition to carboxyls, were connected with a positive influence. The results may be important for elucidating factors affecting iron bioavailability in the small intestine and for the development of foods with improved iron bioavailability.
Susan Salovaara; Ann-Sofie Sandberg; Thomas Andlid
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  50     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-02     Completed Date:  2002-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6233-8     Citation Subset:  IM    
Department of Food Science, Chalmers University of Technology, P.O. Box 5401, SE-402 29 Göteborg, Sweden.
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MeSH Terms
Acetic Acid / pharmacology
Caco-2 Cells / drug effects*,  metabolism*
Carboxylic Acids / pharmacology*
Citric Acid / pharmacology
Ferric Compounds / metabolism
Ferrous Compounds / metabolism
Fumarates / pharmacology
Iron / metabolism*
Malates / pharmacology
Oxalic Acid / pharmacology
Propionic Acids / pharmacology
Succinic Acid / pharmacology
Tartrates / pharmacology
Reg. No./Substance:
0/Carboxylic Acids; 0/Ferric Compounds; 0/Ferrous Compounds; 0/Fumarates; 0/Malates; 0/Propionic Acids; 0/Tartrates; 110-15-6/Succinic Acid; 110-17-8/fumaric acid; 144-62-7/Oxalic Acid; 526-83-0/tartaric acid; 64-19-7/Acetic Acid; 6915-15-7/malic acid; 7439-89-6/Iron; 77-92-9/Citric Acid; 79-09-4/propionic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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