Document Detail

Organic acids in the second morning urine in a healthy Swiss paediatric population.
MedLine Citation:
PMID:  14708889     Owner:  NLM     Status:  MEDLINE    
Organic acid analysis is used for the early detection/ exclusion and for the follow-up of inherited disorders of amino acid and organic acid metabolism. Urinary organic acid concentrations in 417 healthy Caucasian children (1 day to 17 years of age) were determined after liquid solid extraction, as their trimethylsilyl derivatives, by gas chromatography and mass spectrometry. Concentrations of most of the organic acids adjusted for creatinine tend to decrease with age. No differences were found between gender except for the Krebs cycle intermediates in the older age groups. In neonates, the immaturity of the neonatal kidney led to a much larger variation of organic acid levels when related to creatinine. The low number of subjects (n = 36-52) per age class resulted in large 95% confidence intervals of the percentiles used for decision. This must be taken into account when using the data for exclusion or diagnosis of disorders.
Olivier Boulat; Marianne Gradwohl; Vera Matos; Jean-Pierre Guignard; Claude Bachmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  41     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-07     Completed Date:  2004-07-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1642-58     Citation Subset:  IM    
Central Clinical Chemistry Laboratory, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
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MeSH Terms
Carboxylic Acids / urine*
Child, Preschool
European Continental Ancestry Group
Gas Chromatography-Mass Spectrometry / methods*
Infant, Newborn
Organic Chemicals / urine*
Reg. No./Substance:
0/Carboxylic Acids; 0/Organic Chemicals

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