Document Detail

Organ weights, liver constituents, and serum components in growing chicks fed ochratoxin A.
MedLine Citation:
PMID:  2471469     Owner:  NLM     Status:  MEDLINE    
Chicks were fed diets containing 0, 1, 5 and 10 mg/kg ochratoxin A (OA) over a four-week period to study the effects of OA on growth, weight of internal organs, liver RNA, DNA, protein, and glycogen and serum enzymes. Ochratoxin A depressed the rate of growth and relative weight of the bursa of Fabricius, and increased the relative weights of the liver, kidney, pancreas, and various sections of the gastrointestinal tract, but had no effect on the heart and spleen. Concentrations of liver RNA, DNA and protein were decreased while glycogen was increased. Serum alkaline phosphatase and gamma-glutamyl transferase activities, and uric acid and creatinine concentrations were elevated while serum proteins, albumin, phosphorus, potassium, and cholesterol were depressed. The effects of OA were time- and dose-dependent.
O Sreemannarayana; R R Marquardt; A A Frohlich; D Abramson; G D Phillips
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of environmental contamination and toxicology     Volume:  18     ISSN:  0090-4341     ISO Abbreviation:  Arch. Environ. Contam. Toxicol.     Publication Date:    1989 May-Jun
Date Detail:
Created Date:  1989-07-03     Completed Date:  1989-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0357245     Medline TA:  Arch Environ Contam Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  404-10     Citation Subset:  IM    
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MeSH Terms
Animal Feed
Blood Chemical Analysis*
DNA / analysis
Food Contamination
Liver / analysis,  drug effects*
Ochratoxins / toxicity*
Organ Size / drug effects*
RNA / analysis
Reg. No./Substance:
0/Ochratoxins; 303-47-9/ochratoxin A; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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