Document Detail

Organ specificity of metastatic tumor colonization is related to organ-selective growth properties of malignant cells.
MedLine Citation:
PMID:  3733263     Owner:  NLM     Status:  MEDLINE    
In cancers such as malignant melanoma, tumor spread or metastasis occurs preferentially to certain organ sites. Mouse B16 melanoma cell sublines that have been selected sequentially in vivo for enhanced blood-borne colonization of lung, brain, or ovary were tested for their survival and growth stimulation in vitro by soluble factors released from suspensions of mouse lung, brain, liver, ovary or kidney tissues. In general, the growth rate of lung-colonizing B16 cells was stimulated by high concentrations of lung-tissue-derived factors significantly more than by factors from the other tissues, whereas the growth rate of ovary-colonizing B16 cells was stimulated by ovary or lung-tissue-derived factors significantly more than by factors from the other tissues. In contrast, the growth of brain-colonizing B16 cells was not stimulated by factors released from brain tissue. When it occurred, stimulation of B16 cell growth by factors released from mouse organ tissues was dose-dependent. Liver tissue factors, and at high concentrations kidney tissue factors, inhibited cell growth of the B16 sublines, an inhibition correlating with the low potential of B16 cells to colonize liver and kidney in vivo. In addition to preferential target-organ cell adhesion found previously with B16 sublines (Nicolson et al., 1985a), the present results suggest that metastasis to specific organ sites is also dependent on the survival and growth of B16 cells affected by soluble organ-derived factors.
G L Nicolson; K M Dulski
Related Documents :
25242303 - Modulated electro-hyperthermia enhances dendritic cell therapy through an abscopal effe...
20237413 - Triggering of tlr7 and tlr8 expressed by human lung cancer cells induces cell survival ...
22848113 - Where the wild things are: when esotropia misbehaves.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  38     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Neoplasms / secondary
Cell Line
Culture Media
Kidney Neoplasms / secondary
Liver Neoplasms, Experimental / secondary
Lung Neoplasms / secondary
Melanoma / pathology
Neoplasm Metastasis*
Organ Specificity*
Ovarian Neoplasms / secondary
Grant Support
Reg. No./Substance:
0/Culture Media

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characterization of the platelet-aggregating activity of cancer cells with different metastatic pote...
Next Document:  Myocardial infarction and subtotal obstruction of the anterior descending coronary artery caused by ...