Document Detail

Organ-sparing surgery does not lead to greater antisperm antibody levels than orchidectomy.
MedLine Citation:
PMID:  17433029     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess a possible development of antisperm antibodies (ASA), present in a high percentage of infertile patients, after organ-sparing surgery for small testicular tumours, to identify any additional immunogenic effect of this procedure compared with standard orchidectomy. PATIENTS AND METHODS: Samples of sera were assessed from 54 men who had had surgery between 2000 and 2005 for testicular tumour; the men were divided into two groups, i.e. group A (23) had had organ-sparing tumour resection and group B (31) had had inguinal orchidectomy. Other possible causes of ASA besides testicular tumour were excluded in all patients. The blood samples were obtained during follow-up visits and the circulating ASA in serum determined using an enzyme-linked immunosorbent assay. RESULTS: The mean (range) tumour diameter was statistically significantly greater (P < 0.03) in group B, at 33.6 (2-130) mm, than in group A, at 12 (2-30) mm. There were significantly more stromal tumours in group A than group B (P < 0.02). Most importantly, the mean (range) ASA levels were not statistically significantly (P > 0.3) higher in group A, at 29 (15-59) U/mL, than in group B, at 24.8 (12-39) U/mL. There was also no statistically significant correlation between ASA levels and clinical stage, length of follow-up after therapy, patient age, tumour size and type of histology. CONCLUSION: From these data, organ-sparing surgery does not lead to greater ASA levels than orchidectomy and patients are therefore at no greater risk of developing an autoimmune infertility.
Nicolai Leonhartsberger; Christian Gozzi; Thomas Akkad; Brigitte Springer-Stoehr; Georg Bartsch; Hannes Steiner
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Publication Detail:
Type:  Journal Article     Date:  2007-04-13
Journal Detail:
Title:  BJU international     Volume:  100     ISSN:  1464-4096     ISO Abbreviation:  BJU Int.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  371-4     Citation Subset:  IM    
Department of Urology, Medical University Innsbruck, Austria.
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MeSH Terms
Autoantibodies / metabolism*
Chi-Square Distribution
Infertility, Male / immunology,  prevention & control*
Middle Aged
Orchiectomy / methods*
Spermatozoa / immunology*,  metabolism
Statistics, Nonparametric
Testicular Neoplasms / immunology,  surgery*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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