Document Detail


Orexin and psychiatric symptoms in suicide attempters.
MedLine Citation:
PMID:  17141878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The orexins (hypocretins) are recently discovered hypothalamic peptides that are involved in the regulation of sleep, appetite and state of arousal. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symptoms in suicidal patients. METHODS: A total of 101 patients were enrolled in the study shortly after a suicide attempt. All patients underwent a lumbar puncture after a wash-out period during which they did not receive any antipsychotic or antidepressive medication. Structured interviews were performed using the Comprehensive Psychopathological Rating Scale (CPRS). CSF-orexin-A was measured and correlated with ratings of psychiatric symptoms. RESULTS: There were significant and negative correlations between CSF-orexin and the symptoms lassitude (difficulty to initiate activities) and slowness of movement, as well as the ratings of global illness (p<0.005 for all three items, Spearman's rho). LIMITATIONS: Correlation analysis is an indirect method of investigation and does not demonstrate causal relationships. CONCLUSION: Low CSF-orexin levels are related to pronounced symptoms of inertia and reduced motor activity in suicidal patients. Interestingly, the lower the orexin levels, the higher were ratings of overall illness, as observed by a specialist in psychiatry. Our results suggest that reduced orexin levels are involved in the etiology of specific psychiatric symptoms.
Authors:
Lena Brundin; Asa Petersén; Maria Björkqvist; Lil Träskman-Bendz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-12-04
Journal Detail:
Title:  Journal of affective disorders     Volume:  100     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-08-23     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  259-63     Citation Subset:  IM    
Affiliation:
Division of Psychiatry, Department of Clinical Sciences, Lund University, Sweden. Lena.Brundin@med.lu.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Depressive Disorder / cerebrospinal fluid*,  epidemiology*,  psychology
Diagnostic and Statistical Manual of Mental Disorders
Female
Humans
Intracellular Signaling Peptides and Proteins / cerebrospinal fluid*
Male
Middle Aged
Neuropeptides / cerebrospinal fluid*
Suicide, Attempted / statistics & numerical data*
Chemical
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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