| Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways. | |
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MedLine Citation:
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PMID: 12419401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Orexin-A and -B are neuropeptides that are implicated in the regulation of vigilance states and energy homeostasis. Orexins are specifically produced by neurons located within the lateral hypothalamic area (LHA), a region implicated in the regulation of feeding behavior. Here, we examined the functional interactions between orexins and anorectic factors [leptin, alpha-melanocyte-stimulating hormone (alpha-MSH) and glucagon-like peptide-1 (GLP-1)] in rats. Intracerebroventricular injection of orexin-A (10 nmol) potently augmented food intake in rats. Neuropeptide Y (NPY) (0.3 nmol) and galanin (3 nmol) also induced a transient increase in food intake. Both NPY- and galanin-induced feeding behaviors were completely inhibited by preadministration of leptin (3 microg), while the same or a higher dose (10 microg) of leptin only partially inhibited orexin-A or -B-induced increase of food intake. Preadministration of anorectic peptides (alpha-MSH and GLP-1), which are shown to be regulated by leptin, abolished NPY-induced feeding; however, orexin-induced feeding was only partially inhibited by these anorectic peptides. These observations suggest that NPY- and galanin-induced increases of feeding involve a leptin-sensitive pathway, while orexin-induced feeding involves both leptin-sensitive and -insensitive pathways. |
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Authors:
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Y Zhu; A Yamanaka; K Kunii; N Tsujino; K Goto; T Sakurai |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiology & behavior Volume: 77 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-06 Completed Date: 2003-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 251-7 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carrier Proteins / pharmacology* Feeding Behavior / drug effects* Galanin / pharmacology Glucagon / pharmacology Glucagon-Like Peptide 1 Injections, Intraventricular Intracellular Signaling Peptides and Proteins* Leptin / pharmacology* Male Neuropeptides / pharmacology* Peptide Fragments / pharmacology Protein Precursors / pharmacology Rats Rats, Wistar Receptors, G-Protein-Coupled Receptors, Neuropeptide Receptors, Neuropeptide Y / antagonists & inhibitors alpha-MSH / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Leptin; 0/Neuropeptides; 0/Peptide Fragments; 0/Protein Precursors; 0/Receptors, G-Protein-Coupled; 0/Receptors, Neuropeptide; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y-Y1 receptor; 0/orexin receptors; 0/orexins; 581-05-5/alpha-MSH; 88813-36-9/Galanin; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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