Document Detail

Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways.
MedLine Citation:
PMID:  12419401     Owner:  NLM     Status:  MEDLINE    
Orexin-A and -B are neuropeptides that are implicated in the regulation of vigilance states and energy homeostasis. Orexins are specifically produced by neurons located within the lateral hypothalamic area (LHA), a region implicated in the regulation of feeding behavior. Here, we examined the functional interactions between orexins and anorectic factors [leptin, alpha-melanocyte-stimulating hormone (alpha-MSH) and glucagon-like peptide-1 (GLP-1)] in rats. Intracerebroventricular injection of orexin-A (10 nmol) potently augmented food intake in rats. Neuropeptide Y (NPY) (0.3 nmol) and galanin (3 nmol) also induced a transient increase in food intake. Both NPY- and galanin-induced feeding behaviors were completely inhibited by preadministration of leptin (3 microg), while the same or a higher dose (10 microg) of leptin only partially inhibited orexin-A or -B-induced increase of food intake. Preadministration of anorectic peptides (alpha-MSH and GLP-1), which are shown to be regulated by leptin, abolished NPY-induced feeding; however, orexin-induced feeding was only partially inhibited by these anorectic peptides. These observations suggest that NPY- and galanin-induced increases of feeding involve a leptin-sensitive pathway, while orexin-induced feeding involves both leptin-sensitive and -insensitive pathways.
Y Zhu; A Yamanaka; K Kunii; N Tsujino; K Goto; T Sakurai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  77     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-06     Completed Date:  2003-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  251-7     Citation Subset:  IM    
Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
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MeSH Terms
Carrier Proteins / pharmacology*
Feeding Behavior / drug effects*
Galanin / pharmacology
Glucagon / pharmacology
Glucagon-Like Peptide 1
Injections, Intraventricular
Intracellular Signaling Peptides and Proteins*
Leptin / pharmacology*
Neuropeptides / pharmacology*
Peptide Fragments / pharmacology
Protein Precursors / pharmacology
Rats, Wistar
Receptors, G-Protein-Coupled
Receptors, Neuropeptide
Receptors, Neuropeptide Y / antagonists & inhibitors
alpha-MSH / pharmacology
Reg. No./Substance:
0/Carrier Proteins; 0/Intracellular Signaling Peptides and Proteins; 0/Leptin; 0/Neuropeptides; 0/Peptide Fragments; 0/Protein Precursors; 0/Receptors, G-Protein-Coupled; 0/Receptors, Neuropeptide; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y-Y1 receptor; 0/orexin receptors; 0/orexins; 581-05-5/alpha-MSH; 88813-36-9/Galanin; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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