| Orexin A affects ascending contraction depending on downstream cholinergic neurons and descending relaxation through independent pathways in mouse jejunum. | |
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MedLine Citation:
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PMID: 16762378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The involvement of orexin in neural pathways for peristalsis was examined in mouse jejunal segments. Localized distension of the segments using a small balloon resulted in ascending contraction and descending relaxation. Ascending contraction was abolished by atropine and tetrodotoxin. Desensitization to orexin A (OXA) and SB-334867-A, an orexin-1 receptor antagonist, significantly inhibited ascending contraction. Hexamethonium also produced a significant inhibition. Exogenous administration of either OXA or nicotine induced a transient contraction that was completely inhibited by atropine and tetrodotoxin. The OXA-induced contraction was significantly inhibited by hexamethonium and SB-334867-A, whereas the nicotine-induced contraction was not inhibited by SB-334867-A. Descending relaxation was either partially or completely inhibited by l-nitroarginine and tetrodotoxin, respectively. Both SB-334867-A and hexamethonium partially inhibited descending relaxation. A combination of SB-334867-A and hexamethonium had an additive inhibitory effect on descending relaxation. Exogenous OXA, in the presence of atropine, induced a relaxation that was significantly inhibited by both l-nitroarginine and SB-334867-A, but not by hexamethonium. Nicotine in the presence of atropine relaxed the jejunal segment. SB-334867-A, unlike hexamethonium, did not affect nicotine-induced relaxation. These results suggest that OXA plays an important role in the ascending and descending neural reflexes in the mouse jejunum. |
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Authors:
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Yuji Satoh; Yutaka Okishio; Yasu-Taka Azuma; Hidemitsu Nakajima; Fumiaki Hata; Tadayoshi Takeuchi |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-08 |
Journal Detail:
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Title: Neuropharmacology Volume: 51 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-21 Completed Date: 2006-12-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: England |
Other Details:
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Languages: eng Pagination: 466-73 Citation Subset: IM |
Affiliation:
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Department of Veterinary Pharmacology, Graduate school of Life and Environmental Sciences, Osaka Prefecture University, Gakuen-cho 1-1, Sakai 599-9531, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism* Animals Arginine / pharmacology Benzoxazoles / pharmacology Drug Interactions Enzyme Inhibitors / pharmacology Hexamethonium / pharmacology Immunohistochemistry / methods Intracellular Signaling Peptides and Proteins / pharmacology* Jejunum / drug effects*, physiology Male Mice Mice, Inbred ICR Models, Biological Muscle Contraction / drug effects*, physiology Neural Pathways / cytology* Neurons* / drug effects, metabolism, physiology Neuropeptides / pharmacology* Nicotinic Antagonists / pharmacology Nitroarginine / pharmacology Urea / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea; 0/Benzoxazoles; 0/Enzyme Inhibitors; 0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/Nicotinic Antagonists; 0/orexins; 2149-70-4/Nitroarginine; 51-84-3/Acetylcholine; 57-13-6/Urea; 60-26-4/Hexamethonium; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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