Document Detail


Ordered multiple-class ROC analysis with continuous measurements.
MedLine Citation:
PMID:  15505886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Receiver operating characteristic (ROC) curves have been useful in two-group classification problems. In three- and multiple-class diagnostic problems, an ROC surface or hyper-surface can be constructed. The volume under these surfaces can be used for inference using bootstrap techniques or U-statistics theory. In this article, ROC surfaces and hyper-surfaces are defined and their behaviour and utility in multi-group classification problems is investigated. The formulation of the problem is equivalent to what has previously been proposed in the general multi-category classification problem but the definition of ROC surfaces here is less complex and addresses directly the narrower problem of ordered categories in the three-class and, by extension, the multi-class problem applied to continuous and ordinal data. Non-parametric manipulation of both continuous and discrete test data and comparison between two diagnostic tests applied to the same subjects are considered. A three-group classification example in the context of HIV neurological disease is presented and the results are discussed.
Authors:
Christos T Nakas; Constantin T Yiannoutsos
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Statistics in medicine     Volume:  23     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-01     Completed Date:  2005-02-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  3437-49     Citation Subset:  IM    
Copyright Information:
2004 John Wiley & Sons, Ltd.
Affiliation:
Division of Biostatistics, Indiana University School of Medicine, 1050 Wishard Boulevard, RG 4101, Indianapolis, IN 46202-2872, USA.
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MeSH Terms
Descriptor/Qualifier:
AIDS Dementia Complex / pathology
Clinical Trials as Topic / methods
Computer Simulation
Diagnostic Tests, Routine / methods*
HIV / growth & development
HIV Infections / drug therapy,  pathology
Humans
Neuropsychological Tests
ROC Curve*
Grant Support
ID/Acronym/Agency:
P30-CA82709/CA/NCI NIH HHS; R01-MH64409/MH/NIMH NIH HHS; R03-MH060565/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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