Document Detail


Ordered just so: lipid rafts and lymphocyte function.
MedLine Citation:
PMID:  11880687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunologists have long been occupied with the description of cellular activation signaling events that originate with the stimulation of multichain immunoreceptors at the cell surface. These signals are transmitted by a protein-partner-signaling cascade through the cytoplasm to the nucleus, where they culminate in changes in gene expression, metabolic state, and entry into cell cycle. For T cells and B cells, these signaling cascades start with the ligation of the T cell receptor (TCR) and B cell receptor (BCR), respectively, and result in the recruitment and activation of related families of signaling molecules at the cell surface. Until recently, this gathering of signaling proteins was thought to occur within the featureless plasma membrane, a cellular organ that was envisioned as a boundary between the inner and outer components of the cell, but which contributed little to the signaling process. However, the past few years have seen the gradual realization that activation of signaling in lymphocytes takes place in and around specialized membrane subdomains called lipid rafts (also known as DIGs and GEMs). Here, we provide a brief overview of the analogous structures and compositions of lipid raft-associated signaling complexes in T cells and B cells, and the ways in which lymphocytes--and their pathogen adversaries--use lipid rafts to their benefit.
Authors:
Caitlin E Sedwick; Amnon Altman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review     Date:  2002-03-05
Journal Detail:
Title:  Science's STKE : signal transduction knowledge environment     Volume:  2002     ISSN:  1525-8882     ISO Abbreviation:  Sci. STKE     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-03-21     Revised Date:  2009-10-21    
Medline Journal Info:
Nlm Unique ID:  100964423     Medline TA:  Sci STKE     Country:  United States    
Other Details:
Languages:  eng     Pagination:  re2     Citation Subset:  IM    
Affiliation:
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
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MeSH Terms
Descriptor/Qualifier:
Humans
Lymphocyte Subsets / chemistry,  immunology*
Membrane Microdomains / chemistry,  physiology*
Grant Support
ID/Acronym/Agency:
CA35299/CA/NCI NIH HHS; GM50819/GM/NIGMS NIH HHS; PG51127/PG/OAPP OPHS HHS

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