Document Detail


The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate.
MedLine Citation:
PMID:  20159601     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Typical murine epidermis has a patterned structure, seen clearly in ear skin, with regular columns of differentiated cells overlying the proliferative basal layer. It has been proposed that each column is a clonal epidermal proliferative unit maintained by a central stem cell and its transit amplifying cell progeny. An alternative hypothesis is that proliferating basal cells have random fate, the probability of generating cycling or differentiated cells being balanced so homeostasis is achieved. The stochastic model seems irreconcilable with an ordered tissue. Here we use lineage tracing to reveal that basal cells generate clones with highly irregular shapes that contribute progeny to multiple columns. Basal cell fate and cell cycle time is random. Cell columns form due to the properties of postmitotic cells. We conclude that the ordered architecture of the epidermis is maintained by a stochastic progenitor cell population, providing a simple and robust mechanism of homeostasis.
Authors:
David P Doupé; Allon M Klein; Benjamin D Simons; Philip H Jones
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental cell     Volume:  18     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-03-30     Revised Date:  2014-05-13    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult Stem Cells / cytology*
Animals
Cell Cycle
Cell Differentiation
Cell Proliferation
Cell Shape
Ear, External / anatomy & histology,  cytology*
Epidermis / anatomy & histology,  cytology*
Homeostasis
Luminescent Proteins / genetics,  metabolism
Mice
Mice, Transgenic
Models, Biological
Recombinant Proteins / genetics,  metabolism
Stochastic Processes
Grant Support
ID/Acronym/Agency:
G0700600/1//National Centre for the Replacement, Refinement and Reduction of Animals in Research; G0800784//Medical Research Council; MC_U105370181//Medical Research Council; //Medical Research Council
Chemical
Reg. No./Substance:
0/Luminescent Proteins; 0/Recombinant Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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