| Order-dependent modulation of directional signals in the supplementary and presupplementary motor areas. | |
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MedLine Citation:
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PMID: 18077677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To maximize reward and minimize effort, animals must often execute multiple movements in a timely and orderly manner. Such movement sequences must be usually discovered through experience, and during this process, signals related to the animal's action, its ordinal position in the sequence, and subsequent reward need to be properly integrated. To investigate the role of the primate medial frontal cortex in planning and controlling multiple movements, monkeys were trained to produce a series of hand movements instructed by visual stimuli. We manipulated the number of movements in a sequence across trials, making it possible to dissociate the effects of the ordinal position of a given movement and the number of remaining movements necessary to obtain reward. Neurons in the supplementary and presupplementary motor areas modulated their activity according to the number of remaining movements, more often than in relation to the ordinal position, suggesting that they might encode signals related to the timing of reward or its temporally discounted value. In both cortical areas, signals related to the number of remaining movements and those related to movement direction were often combined multiplicatively, suggesting that the gain of the signals related to movements might be modulated by motivational factors. Finally, compared with the supplementary motor area, neurons in the presupplementary motor area were more likely to increase their activity when the number of remaining movements is large. These results suggest that these two areas might play complementary roles in controlling movement sequences. |
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Authors:
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Jeong-Woo Sohn; Daeyeol Lee |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 27 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-13 Completed Date: 2008-01-22 Revised Date: 2011-01-31 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 13655-66 Citation Subset: IM |
Affiliation:
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Department of Brain and Cognitive Sciences, Center for Visual Science, University of Rochester, Rochester, New York 14627, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / physiology Electrodes, Implanted Fixation, Ocular / physiology Frontal Lobe / physiology* Hand / physiology Linear Models Macaca mulatta Male Models, Neurological Movement / physiology Photic Stimulation / methods Psychomotor Performance / physiology Reaction Time / physiology Reward |
| Grant Support | |
ID/Acronym/Agency:
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MH059216/MH/NIMH NIH HHS; R01 MH059216-10/MH/NIMH NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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