Document Detail

Order by disorder in plant signaling.
MedLine Citation:
PMID:  22819467     Owner:  NLM     Status:  Publisher    
Protein intrinsic disorder (ID), referring to the lack of a fixed tertiary structure, is an emerging topic in plant science. Proteins with ID challenge our perception of protein interactions because of their malleable behavior. They are abundant in highly regulated processes such as cellular signaling and transcription, where they exploit the flexibility of ID. In this opinion article we highlight trends in the field of protein ID and discuss its implications for interactions between plant transcription factors (TFs) and the cellular signaling hub protein RADICAL-INDUCED CELL DEATH 1 (RCD1). We envision RCD1-TF interactions as models for translating knowledge of ID-based interactions in vitro to the organismal level in vivo, and urge increased focus on ID in basic plant research and agricultural sciences.
Birthe B Kragelund; Michael Krogh Jensen; Karen Skriver
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-20
Journal Detail:
Title:  Trends in plant science     Volume:  -     ISSN:  1878-4372     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9890299     Medline TA:  Trends Plant Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Biomolecular Sciences, Department of Biology, University of Copenhagen, Ole Maaloes Vej 5, DK-2200 Copenhagen N, Denmark.
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