Document Detail

Orchidectomy following failure of antiandrogen monotherapy in patients with metastatic prostate cancer.
MedLine Citation:
PMID:  11528188     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Patients with metastatic prostate cancer who are initially treated by oral antiandrogens and then have progressive disease may be offered surgical castration as a second-line treatment. Twenty-eight such patients were reviewed to determine the outcome in terms of secondary PSA response, symptomatic relief and disease-specific survival. MATERIALS AND METHODS: Retrospective chart-based review of patients undergoing bilateral scrotal orchidectomy after failure of antiandrogen monotherapy. RESULTS: Patients who had a >50% reduction in PSA at 12 weeks' postorchidectomy had significantly greater duration of PSA response and disease-specific survival. 64% of patients who had bone pain prior to orchidectomy had some relief of symptoms postoperatively. No prognostic indicators of improved survival were identified. CONCLUSION: Orchidectomy as a secondary hormonal treatment following relapse on antiandrogens does produce a response in terms of PSA level and symptoms in some patients.
A Tan; J Tuckey; M Rice
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European urology     Volume:  40     ISSN:  0302-2838     ISO Abbreviation:  Eur. Urol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-30     Completed Date:  2002-07-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  130-3; discussion 134     Citation Subset:  IM    
Department of Urology, Auckland Hospital, Auckland, New Zealand.
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MeSH Terms
Aged, 80 and over
Androgen Antagonists / therapeutic use
Bone Neoplasms / secondary*,  surgery*
Middle Aged
Prostatic Neoplasms / drug therapy,  pathology*,  surgery*
Treatment Failure
Reg. No./Substance:
0/Androgen Antagonists

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