| Orchidectomy following failure of antiandrogen monotherapy in patients with metastatic prostate cancer. | |
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MedLine Citation:
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PMID: 11528188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Patients with metastatic prostate cancer who are initially treated by oral antiandrogens and then have progressive disease may be offered surgical castration as a second-line treatment. Twenty-eight such patients were reviewed to determine the outcome in terms of secondary PSA response, symptomatic relief and disease-specific survival. MATERIALS AND METHODS: Retrospective chart-based review of patients undergoing bilateral scrotal orchidectomy after failure of antiandrogen monotherapy. RESULTS: Patients who had a >50% reduction in PSA at 12 weeks' postorchidectomy had significantly greater duration of PSA response and disease-specific survival. 64% of patients who had bone pain prior to orchidectomy had some relief of symptoms postoperatively. No prognostic indicators of improved survival were identified. CONCLUSION: Orchidectomy as a secondary hormonal treatment following relapse on antiandrogens does produce a response in terms of PSA level and symptoms in some patients. |
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Authors:
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A Tan; J Tuckey; M Rice |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European urology Volume: 40 ISSN: 0302-2838 ISO Abbreviation: Eur. Urol. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-08-30 Completed Date: 2002-07-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7512719 Medline TA: Eur Urol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 130-3; discussion 134 Citation Subset: IM |
Affiliation:
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Department of Urology, Auckland Hospital, Auckland, New Zealand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Androgen Antagonists / therapeutic use Bone Neoplasms / secondary*, surgery* Humans Male Middle Aged Orchiectomy* Prostatic Neoplasms / drug therapy, pathology*, surgery* Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Androgen Antagonists |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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