Document Detail

Orbital steroid injection versus oral steroid therapy in management of thyroid-related ophthalmopathy.
MedLine Citation:
PMID:  20497432     Owner:  NLM     Status:  In-Process    
BACKGROUND: The aim of this study was to evaluate the efficacy, safety and complications of orbital steroid injection versus oral steroid therapy in the management of thyroid-related ophthalmopathy.
METHODS: A total of 29 patients suffering from thyroid ophthalmopathy were included in this study. Patients were randomized into two groups: group I included 15 patients treated with oral prednisolone and group II included 14 patients treated with peribulbar triamcinolone orbital injection. Only 12 patients in both groups (16 female and 8 male) completed the study.
RESULTS: Both groups showed improvement in symptoms and in clinical evidence of inflammation with improvement of eye movement and proptosis in most cases. Mean exophthalmometry value before treatment was 22.6 ± 1.98 mm that decreased to 18.6 ± 0.996 mm in group I, compared with 23 ± 1.86 mm that decreased to 19.08 ± 1.16 mm in group II. Mean initial clinical activity score was 4.75 ± 1.2 and 5 ± 1.3 for group I and group II before treatment, respectively, which dropped to 0.83 ± 1.2 and 0.83 ± 1.02, 6 months after treatment, respectively. There was no change in the best-corrected visual acuity in both groups. There was an increase in body weight, blood sugar, blood pressure and gastritis in group I in 66.7%, 33.3%, 50% and 75%, respectively, compared with 0%, 0%, 8.3% and 8.3% in group II. No adverse local side effects were observed in group II.
CONCLUSION: Orbital steroid injection for thyroid-related ophthalmopathy is effective and safe. It eliminates the adverse reactions associated with oral corticosteroid use.
Ayman A Alkawas; Atef M Hussein; Ezzat A Shahien
Publication Detail:
Type:  Journal Article     Date:  2010-07-09
Journal Detail:
Title:  Clinical & experimental ophthalmology     Volume:  38     ISSN:  1442-9071     ISO Abbreviation:  Clin. Experiment. Ophthalmol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100896531     Medline TA:  Clin Experiment Ophthalmol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  692-7     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Journal compilation © 2010 Royal Australian and New Zealand College of Ophthalmologists.
Ophthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt.
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Comment In:
Clin Experiment Ophthalmol. 2010 Oct;38(7):657-8   [PMID:  20946224 ]

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