| Orbital sporadic Burkitt lymphoma in an adult diabetic African American female and a review of adult orbital cases. | |
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MedLine Citation:
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PMID: 21573040 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A case of sporadic Burkitt lymphoma (sBL) presenting with jaw and lid involvement in a diabetic adult African American female and a review of adult orbital Burkitt lymphoma cases are presented. Lid edema, visual loss, ophthalmoparesis, proptosis, and sinusitis progressed over 4 weeks despite antibiotic and steroid treatment. Upper lid biopsy histopathological evaluation and immunophenotyping revealed a homogenous mass of atypical CD10 and CD20-negative B-cells and tingible body macrophages yielding a "starry sky" appearance. Cytogenetic analysis detected a minor variant c-MYC translocation, but no Epstein-Barr virus RNA. Detection of multiple lesions prompted a diagnosis of stage IV disease that totally regressed following radiation and chemotherapy. Review results of the six adult orbital sBL cases support a poor prognosis and a heightened suspicion of variant CD10, CD20 and BCL6 positive sBL in adults presenting with jaw pain and rapidly progressive orbital symptoms, particularly in female, African American, and diabetic patients. |
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Authors:
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John Carmody; Raghunath P Misra; Marlyn P Langford; William A Byrd; Lauren Ditta; Bryan Vekovius; Donald E Texada |
Publication Detail:
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Type: Journal Article Date: 2011-04-20 |
Journal Detail:
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Title: Clinical ophthalmology (Auckland, N.Z.) Volume: 5 ISSN: 1177-5483 ISO Abbreviation: Clin Ophthalmol Publication Date: 2011 |
Date Detail:
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Created Date: 2011-05-16 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101321512 Medline TA: Clin Ophthalmol Country: New Zealand |
Other Details:
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Languages: eng Pagination: 509-15 Citation Subset: - |
Affiliation:
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Department of Ophthalmology. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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