Document Detail

Orbital solitary fibrous tumor with aggressive behaviorThree cases and review of the literature.
MedLine Citation:
PMID:  12136289     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Solitary fibrous tumor (SFT) is a rare spindle cell tumor that arises most often in the visceral pleura; however, a review of the literature shows at least 31 cases occurring in the orbit.
METHODS: A retrospective case series of three patients with orbital SFT: a 50-year-old man, observed in 1997, with an angioma-like lesion in the upper half of the orbit causing osteolysis of the orbital roof; a 24-year-old man, observed in 1992, with a superotemporal mass in the right orbit occupying the lacrimal gland region, firstly diagnosed as schwannoma, recurring 4 years after dacryoadenectomy; a 70-year-old man, with a retrobulbar mass diagnosed on a biopsy as hemangiopericytoma, recurring and infiltrating the orbital roof 4 years after surgery.
RESULTS: A review of the literature and presentation of three cases of SFT which showed infiltration of the orbital roof and/or recurrence.
CONCLUSIONS: Our cases provide evidence of how orbital SFT can behave aggressively and mimic other orbital tumors, thus making mandatory the consideration of this relatively new entity in common clinical practice as well as careful follow-up. Their aggressive growth is unusual, described in only 6 of the 31 cases so far reported in the literature. Immunohistochemistry is of importance for the diagnosis, since CD34 immunoreactivity is peculiar to SFT.
Ennio Polito; Gian Marco Tosi; Paolo Toti; Karin Schürfeld; Aldo Caporossi
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2002-06-20
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  240     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-23     Completed Date:  2002-10-03     Revised Date:  2012-10-31    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  570-4     Citation Subset:  IM    
Department of Ophthalmology and Neurosurgery, University of Siena, Via delle Scotte, 6, Italy.
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MeSH Terms
Antigens, CD34 / metabolism
Diagnosis, Differential
Fibroma / metabolism,  pathology*,  radiography
Immunoenzyme Techniques
Middle Aged
Orbital Neoplasms / metabolism,  pathology*,  radiography
Retrospective Studies
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Antigens, CD34; 0/Tumor Markers, Biological

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