Document Detail

Orbital prefrontal cortex and guidance of instrumental behaviour in rats under reversal conditions.
MedLine Citation:
PMID:  12842295     Owner:  NLM     Status:  MEDLINE    
The orbital prefrontal cortex (OPFC) is suggested to be part of a circuitry mediating the perception of reward and the initiation of adaptive behavioural responses. In the present study, we investigated in rats changes of goal-directed behaviour after bilateral OPFC-lesions by N-methyl-D-aspartate (NMDA) in more detail. A reaction time (RT) task was used which is sensitive to subtle changes in discriminative guidance of instrumental behaviour by the anticipated reward magnitudes. The task demands conditioned lever release triggered by an imperative stimulus. The upcoming reward magnitude (five or one food pellet) for each trial was randomly chosen and signalled in advance by distinct instructive stimuli. In trained rats, RTs of instrumental responses were determined by the two distinct stimulus-reward magnitude contingencies, i.e. RTs were shorter to the instructive stimulus predictive of the higher reward magnitude. Results show that lesions of the OPFC did not impair discriminative guidance of behavioural responses according to preoperatively acquired stimulus-reward magnitude contingencies. However, guidance of instrumental behaviour was altered in lesioned rats after a reversal of the stimulus-reward magnitude contingencies. The data add further support to the hypothesis that the rat OPFC is not involved in retrieval of acquired stimulus-reward magnitude contingencies but in integration of incentive information to guide behaviour after a reversal of stimulus-reward contingencies.
Ines Bohn; Christian Giertler; Wolfgang Hauber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Behavioural brain research     Volume:  143     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
Abteilung Tierphysiologie, Biologisches Institut, Universität Stuttgart, D-70550, Stuttgart, Germany.
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MeSH Terms
Adaptation, Physiological
Analysis of Variance
Brain Diseases / chemically induced,  pathology
Conditioning, Operant / physiology*
Discrimination (Psychology) / physiology*
Excitatory Amino Acid Agonists
Prefrontal Cortex / pathology,  physiology*
Rats, Sprague-Dawley
Reaction Time / physiology
Reinforcement (Psychology)
Reversal Learning
Reg. No./Substance:
0/Excitatory Amino Acid Agonists; 6384-92-5/N-Methylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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