Document Detail

Orbital eosinophilic angiocentric fibrosis case report and review of the literature.
MedLine Citation:
PMID:  16324746     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To report a patient with a rare case of orbital eosinophilic angiocentric fibrosis (EAF) and to review the literature. DESIGN: Interventional case report. METHODS: A 61-year-old man presented with a 6-week history of right periorbital edema and painless proptosis. Examination revealed a nonaxial proptosis, lateral globe displacement, and mild limitation in right eye adduction. MAIN OUTCOME MEASURES: Clinical course and radiological and histological findings. RESULTS: Orbital imaging revealed a right medial orbital mass with involvement of middle ethmoidal air cells. An orbital biopsy of the mass demonstrated an inflammatory infiltrate with a marked eosinophilic component, onion skinning of vessels, and surrounding fibrosis. The diagnosis of orbital EAF was made. There was no response to a 3-month treatment course with systemic steroids, but the patient did not want any further surgical interventions. CONCLUSION: Although orbital EAF is rare, ophthalmologists need to be aware of this entity, as it may invade the orbit from the sinonasal tract or present as a localized orbital mass. The presence of even minimal sinus involvement and the characteristic histopathology are useful in establishing the correct diagnosis.
Igal Leibovitch; Craig L James; Peter J Wormald; Dinesh Selva
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-12-01
Journal Detail:
Title:  Ophthalmology     Volume:  113     ISSN:  1549-4713     ISO Abbreviation:  Ophthalmology     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-03     Completed Date:  2006-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  148-52     Citation Subset:  IM    
Oculoplastic and Orbital Unit, Department of Ophthalmology and Visual Sciences, University of Adelaide, Adelaide, SA, Australia.
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MeSH Terms
Eosinophilic Granuloma / drug therapy,  pathology*,  radiography
Eosinophils / pathology*
Glucocorticoids / therapeutic use
Magnetic Resonance Imaging
Middle Aged
Orbital Diseases / drug therapy,  pathology*,  radiography
Prednisolone / therapeutic use
Tomography, X-Ray Computed
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone

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