| Orbital bleeding in rats while under diethylether anaesthesia does not influence telemetrically determined heart rate, body temperature, locomotor and eating activity when compared with anaesthesia alone. | |
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MedLine Citation:
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PMID: 9230509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The question addressed was whether orbital bleeding in rats, while under diethylether anaesthesia, affects their locomotor activity body core temperature, heart rate rhythm and eating pattern. Roman High Avoidance (RHA) and Roman Low Avoidance (RLA) rats were used to enhance generalization of the results. Orbital bleeding when the rats were under diethylether anaesthesia was compared with diethylether anaesthesia alone. To take into account any effects of handling, the rats were also subjected to sham anaesthesia. The RHA rats urinated more during anaesthesia, needed more time to recover from the anaesthesia and showed a greater endocrine stress response to diethylether anaesthesia when compared with the RLA rats. During anaesthesia, the RHA rats showed a greater fall of body temperature and bradycardia than did the RLA rats. Diethylether anaesthesia reduced locomotor activity in the RHA rats, but had no effect in the RLA rats. In neither RHA nor RLA rats did anaesthesia plus orbital puncture, versus anaesthesia alone, influence body temperature, heart rate rhythm, locomotor and eating activity. The lack of effect of orbital puncture occurred both in the short term (within 2h) and long term (within 48 hours) and thus this study indicates that orbital puncture had, at least with respect to variables measured in the present study, no effect superimposed on that of diethylether anaesthesia. |
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Authors:
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H Van Herck; S F De Boer; A P Hesp; H A Van Lith; V Baumans; A C Beynen |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Laboratory animals Volume: 31 ISSN: 0023-6772 ISO Abbreviation: Lab. Anim. Publication Date: 1997 Jul |
Date Detail:
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Created Date: 1997-10-09 Completed Date: 1997-10-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0112725 Medline TA: Lab Anim Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 271-8 Citation Subset: IM |
Affiliation:
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Central Laboratory Animal Institute, Utrecht University, The Netherlands. HvH@gdl.ruu.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia
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adverse effects,
veterinary* Anesthetics, Inhalation / adverse effects* Animals Blood Glucose / analysis Blood Specimen Collection / adverse effects, methods, veterinary* Body Temperature / physiology Corticosterone / blood Eating / physiology Epinephrine / blood Ether, Ethyl / adverse effects* Heart Rate / physiology Male Motor Activity / physiology Norepinephrine / blood Orbit Rats Telemetry / veterinary |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Blood Glucose; 50-22-6/Corticosterone; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 60-29-7/Ether, Ethyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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