| Orally disintegrating and oral standard olanzapine tablets similarly elevate the homeostasis model assessment of insulin resistance index and plasma triglyceride levels in 12 healthy men: a randomized crossover study. | |
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MedLine Citation:
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PMID: 20441717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Treatment with olanzapine is associated with obesity, diabetes mellitus, and dyslipidemia. Reports have indicated that orally disintegrating tablets (ODT) cause less weight gain than oral standard tablets (OST). The aim of this study was to compare the effect of short-term treatment with these 2 distinct olanzapine formulations on glucose and lipid metabolism in healthy men. METHOD: Twelve healthy men (mean ± SEM age: 25.1 ± 5.5 years) received olanzapine ODT (10 mg od, 8 days), olanzapine OST (10 mg od, 8 days), or no intervention in a randomized crossover design. At breakfast and dinner, glucose, insulin, free fatty acids (FFA), and triglyceride concentrations were measured at 10-minute intervals from 30 minutes prior to 2 hours after ingestion of standard meals. Leptin and adiponectin concentrations were measured at 20- and 30-minute intervals, respectively, between 0000h-1200h. Physical activity was assessed with an accelerometer. Fuel oxidation was measured in fasting condition by indirect calorimetry. The study was conducted from April 2006 through September 2006. RESULTS: Treatment with olanzapine ODT and OST equally elevated the homeostasis model assessment of insulin resistance (HOMA-IR) (P = .005). At breakfast, both formulations equally increased fasting and postprandial triglyceride concentrations (P = .013 and P = .005, respectively) while decreasing fasting and postprandial FFA concentrations (P = .004 and P = .009, respectively). Body weight, body composition, physical activity, or fuel oxidation did not differ between treatment modalities. CONCLUSIONS: Eight days of treatment with both olanzapine formulations similarly increased HOMA-IR and triglyceride concentrations and decreased FFA concentrations in response to standard meals without affecting anthropometrics or physical activity. These data suggest that olanzapine hampers insulin action via mechanistic routes other than body adiposity or physical inactivity. TRIAL REGISTRATION: controlled-trials.com. Identifier: ISRCTN17632637. |
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Authors:
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Solrun Vidarsdottir; Pauline Vlug; Ferdinand Roelfsema; Marijke Frölich; Hanno Pijl |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-04-20 |
Journal Detail:
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Title: The Journal of clinical psychiatry Volume: 71 ISSN: 1555-2101 ISO Abbreviation: J Clin Psychiatry Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-06 Completed Date: 2010-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7801243 Medline TA: J Clin Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 1205-11 Citation Subset: IM |
Copyright Information:
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© Copyright 2010 Physicians Postgraduate Press, Inc. |
Affiliation:
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Department of Endocrinology and Metabolism, Leiden University Medical Center, Leiden, The Netherlands. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ISRCTN/ISRCTN17632637 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood Adult Antipsychotic Agents / pharmacology* Benzodiazepines / pharmacology* Blood Glucose / metabolism Cross-Over Studies Dosage Forms Energy Metabolism / drug effects Fatty Acids, Nonesterified / blood Homeostasis / drug effects* Humans Insulin / blood Insulin Resistance / physiology* Leptin / blood Male Motor Activity / physiology Reference Values Triglycerides / blood* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Antipsychotic Agents; 0/Blood Glucose; 0/Dosage Forms; 0/Fatty Acids, Nonesterified; 0/Leptin; 0/Triglycerides; 11061-68-0/Insulin; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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