Document Detail

Orally administered novokinin, an angiotensin AT2 receptor agonist, suppresses food intake via prostaglandin E2-dependent mechanism in mice.
MedLine Citation:
PMID:  19463743     Owner:  NLM     Status:  MEDLINE    
Novokinin (Arg-Pro-Leu-Lys-Pro-Trp), having affinity for the AT(2) receptor, is a potent vasorelaxing and hypotensive peptide designed based on the structure of ovokinin(2-7), a bioactive peptide derived from ovalbumin. Here we show that intracerebroventricularly (i.c.v.) administered novokinin dose-dependently suppresses food intake at a dose of 30-100 nmol/mouse in fasted conscious mice. Orally administered novokinin (30-100mg/kg) also suppressed food intake. Novokinin suppressed food intake in wild-type and AT(1) receptor-knockout mice but not in AT(2) receptor-knockout mice after i.c.v. or oral administration. Novokinin-induced anorexigenic activity after i.c.v. administration was blocked by indomethacin, a cyclooxygenase inhibitor, or ONO-AE3-208, an antagonist for EP(4) receptor for PGE(2). Taken together, novokinin may suppress food intake via activation of PGE(2)-EP(4), downstream of the AT(2) receptor.
Kousaku Ohinata; Yoko Fujiwata; Fukumoto Shingo; Iwai Masaru; Horiuchi Masatsugu; Masaaki Yoshikawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-24
Journal Detail:
Title:  Peptides     Volume:  30     ISSN:  1873-5169     ISO Abbreviation:  Peptides     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1105-8     Citation Subset:  IM    
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan.
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MeSH Terms
Dinoprostone / antagonists & inhibitors,  metabolism*
Dose-Response Relationship, Drug
Eating / drug effects*
Indomethacin / pharmacology
Injections, Intraventricular
Mice, Inbred C57BL
Mice, Knockout
Motor Activity / drug effects
Naphthalenes / pharmacology
Oligopeptides / administration & dosage*,  antagonists & inhibitors
Phenylbutyrates / pharmacology
Receptor, Angiotensin, Type 2 / agonists*
Time Factors
Reg. No./Substance:
0/4-(4-cyano-2-(2-(4-fluoronaphthalen-1-yl)propionylamino)phenyl)butyric acid; 0/Arg-Pro-Leu-Lys-Pro-Trp; 0/Naphthalenes; 0/Oligopeptides; 0/Phenylbutyrates; 0/Receptor, Angiotensin, Type 2; 363-24-6/Dinoprostone; 53-86-1/Indomethacin

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