| Oral vitamin C administration reduces early recurrence rates after electrical cardioversion of persistent atrial fibrillation and attenuates associated inflammation. | |
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MedLine Citation:
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PMID: 15982504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Inflammation and oxidative stress have been recently implicated in the pathophysiology of atrial fibrillation (AF). The aim of this study was to examine the potential benefit of vitamin C on the early recurrence rates and on inflammatory indices after successful cardioversion of persistent AF, as well as to investigate the time course of changes in these indices post-cardioversion. METHODS: We prospectively studied 44 consecutive patients after successful electrical cardioversion of persistent AF. All patients received standard treatment and were randomised in one to one fashion to either oral vitamin C administration or no additional therapy. We followed-up the patients for 7 days performing successive measurements of white blood cell (WBC) count, C-reactive protein (CRP), fibrinogen, and ferritin levels. RESULTS: One week after successful cardioversion, AF recurred in 4.5% of patients in the vitamin C group and in 36.3% of patients in the control group (p=0.024). Compared to baseline values, inflammatory indices decreased after cardioversion in patients receiving vitamin C but did not change significantly in the control group. A significant variance was found in the serial measurements of WBC counts (F=5.86, p=0.001) and of fibrinogen levels (F=4.10, p=0.0084) in the two groups. In the vitamin C group CRP levels were lower on the seventh day (p<0.05). CRP and fibrinogen levels were higher in patients who relapsed into AF compared to patients who maintained sinus rhythm (F=2.77, p=0.044 and F=3.51, p=0.017, respectively). CONCLUSIONS: These findings suggest that vitamin C reduces the early recurrence rates after cardioversion of persistent AF and attenuates the associated low-level inflammation. These effects indicate that therapeutic approaches targeting at inflammation and oxidative stress may exert favourable effects on atrial electrical remodeling. |
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Authors:
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Panagiotis Korantzopoulos; Theofilos M Kolettis; Evaggelos Kountouris; Vasiliki Dimitroula; Pavlos Karanikis; Eugenia Pappa; Konstantinos Siogas; John A Goudevenos |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: International journal of cardiology Volume: 102 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-28 Completed Date: 2005-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 321-6 Citation Subset: IM |
Affiliation:
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Department of Cardiology, G. Hatzikosta General Hospital, 45001 Ioannina, Greece. pkor@oneway.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Antioxidants / administration & dosage* Ascorbic Acid / administration & dosage* Atrial Fibrillation / epidemiology, physiopathology, therapy* Biological Markers / blood C-Reactive Protein / metabolism Echocardiography Electric Countershock / adverse effects* Electrocardiography / drug effects Female Ferritins / blood Fibrinogen / metabolism Follow-Up Studies Heart Atria / ultrasonography Humans Incidence Inflammation / blood, drug therapy, etiology Leukocyte Count Male Myocarditis / blood, drug therapy*, etiology Nephelometry and Turbidimetry Oxidative Stress / physiology Prospective Studies Recurrence / prevention & control Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Biological Markers; 50-81-7/Ascorbic Acid; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins |
| Comments/Corrections | |
Comment In:
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Int J Cardiol. 2005 Oct 10;104(3):361-2
[PMID:
16087256
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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