Document Detail

Oral tuberculosis: a clinical evaluation of 42 cases.
MedLine Citation:
PMID:  10673784     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: A retrospective review of a large series of oro-facial cases of tuberculosis to analyse clinical, histopathological, and radiological aspects, as well as those of chemotherapy. MATERIALS AND METHODS: A total of 42 cases of tuberculosis of the oro-facial region were examined. Thirteen patients had a primary form and 29 a secondary form of the disease. Diagnosis was based on careful clinical examination, Mantoux reaction, histopathological examination, microbiological cultures and immunological investigation with the detection of antibodies against Mycobacteria in the patients' serum (ELISA). RESULTS: Cases examined consisted of 27 males and 15 females. The age range was 3 to 73 years (mean age 31 years). Clinical manifestations comprised oral ulcers in 69.1%, bone involvement in 21.4%, and salivary gland and/or lymph node involvement in 14.3%. A total of 79.4% patients with secondary disease had pulmonary lesions, 15 of whom showed clinical and radiological signs of activity; there was one case of bilateral renal lesions and two of skin lesions. CONCLUSIONS: Oro-facial tuberculosis is often difficult to diagnose and it should be an important consideration in the differential diagnosis of lesions that appear in the oral cavity. The most important diagnostic tools remain a careful clinical evaluation, biopsy for histologic study, as well as acid-fast stains, culture, and immunological assays, and skin testing.
M D Mignogna; L L Muzio; G Favia; E Ruoppo; G Sammartino; C Zarrelli; E Bucci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral diseases     Volume:  6     ISSN:  1354-523X     ISO Abbreviation:  Oral Dis     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2001-01-29     Completed Date:  2001-02-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  D    
Division of Oral Medicine, Faculty of Medicine, University Federico II, Naples, Italy.
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MeSH Terms
Antibodies, Bacterial / blood
Child, Preschool
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Jaw Diseases / microbiology
Middle Aged
Mycobacterium tuberculosis / growth & development,  immunology
Oral Ulcer / microbiology
Physical Examination
Retrospective Studies
Salivary Gland Diseases / microbiology
Tuberculin Test
Tuberculosis, Cutaneous / diagnosis
Tuberculosis, Lymph Node / diagnosis
Tuberculosis, Oral / diagnosis*
Tuberculosis, Osteoarticular / diagnosis
Tuberculosis, Pulmonary / diagnosis
Tuberculosis, Renal / diagnosis
Reg. No./Substance:
0/Antibodies, Bacterial

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