| Oral treatment of ichthyosis by the cytochrome P-450 inhibitor liarozole. | |
| | |
MedLine Citation:
|
PMID: 9039298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Liarozole, a novel imidazole derivative, inhibits the cytochrome P450-dependent 4-hydroxylation of retinoic acid, resulting in increased tissue levels of retinoic acid. Twelve male patients with ichthyosis were given oral liarozole, 150 mg twice daily, in an open study for 12 weeks. Immunohistochemical parameters of inflammation, epidermal proliferation and differentiation were assessed before and after treatment. Extent and severity of the skin lesions was markedly reduced in all patients. Clinical side-effects were reminiscent of those with synthetic retinoids. No relevant changes were found in the haematological, urinary and biochemical parameters. Immunohistochemical assessment showed a statistically significant induction of keratin 4 after liarozole treatment in 10 of 12 patients. In two of these patients keratin 13 was induced. This open study showed that oral liarozole treatment was efficacious and well tolerated in the treatment of different types of ichthyosis. The immunohistochemical results suggest a retinoid mechanism as the mode of action. |
| | |
Authors:
|
G P Lucker; A M Heremans; P J Boegheim; P C van de Kerkhof; P M Steijlen |
Related Documents
:
|
21537528 - Importance to include the term superficial musculoaponeurotic system in medical subject... 19439878 - Intralesional bleomycin in the treatment of cutaneous warts: a randomized clinical tria... 18547498 - The duration of clinical remission of photochemotherapy and narrow-band uv-b photothera... 17135738 - Efficacy results of a 52-week, randomised, double-blind, safety study of a calcipotriol... 20632098 - Prospective evaluation of gastroenterologist-guided, nurse-administered standard sedati... 15251798 - Recombinant human granulocyte colony-stimulating factor in treatment of methimazole-ind... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The British journal of dermatology Volume: 136 ISSN: 0007-0963 ISO Abbreviation: Br. J. Dermatol. Publication Date: 1997 Jan |
Date Detail:
|
Created Date: 1997-03-11 Completed Date: 1997-03-11 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 71-5 Citation Subset: IM |
Affiliation:
|
Department of Dermatology, University Hospital, Nijmegen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Androgen Antagonists / therapeutic use* Cytochrome P-450 Enzyme System / antagonists & inhibitors* Follow-Up Studies Humans Ichthyosis / drug therapy*, metabolism, pathology Imidazoles / therapeutic use* Keratins / metabolism Male Middle Aged Prospective Studies Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
|
0/Androgen Antagonists; 0/Imidazoles; 115575-11-6/liarozole; 68238-35-7/Keratins; 9035-51-2/Cytochrome P-450 Enzyme System |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Post-adolescent acne: a review of clinical features.
Next Document: Long-term efficacy and safety of cyclosporin in severe adult atopic dermatitis.