Document Detail

Oral and topical adrenergic beta-receptor blockers in glaucoma treatment. A multicenter study.
MedLine Citation:
PMID:  6391072     Owner:  NLM     Status:  MEDLINE    
In a long-term multicenter open randomized study of 103 patients with glaucoma or intraocular hypertension, oral propranolol combined with 2% pilocarpine was compared with 0.5% topical timolol also combined with 2% pilocarpine, with respect to the effects on intraocular pressure and other signs of glaucoma. The results showed that the hypotensive effects were highly significant and equal for both treatments. There were no significant differences between the 2 groups in the amount of cupping of the nerve head or the visual field defects developing during treatment. An additive hypotensive effect was recorded when both propranolol and timolol were combined with pilocarpine, which indicates the development of tolerance to both beta-blockers. Pulse rate and blood pressure were moderately reduced in both groups, both significantly more so in the propranolol group. The investigation indicates that when combined with pilocarpine the 2 adrenergic beta-receptor blockers are equally effective. We believe that oral propranolol can improve drug compliance in the treatment of glaucoma.
A Ohrström; O Kättström; W Polland; J Mortensen; B Stenström
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta ophthalmologica     Volume:  62     ISSN:  0001-639X     ISO Abbreviation:  Acta Ophthalmol (Copenh)     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-01-18     Completed Date:  1985-01-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370347     Medline TA:  Acta Ophthalmol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  681-95     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Clinical Trials as Topic
Glaucoma / drug therapy*
Glaucoma, Open-Angle / drug therapy*
Hemodynamics / drug effects
Ophthalmic Solutions
Pilocarpine / administration & dosage*
Propranolol / administration & dosage*,  adverse effects
Random Allocation
Timolol / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Ophthalmic Solutions; 26839-75-8/Timolol; 525-66-6/Propranolol; 92-13-7/Pilocarpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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