| Oral and topical adrenergic beta-receptor blockers in glaucoma treatment. A multicenter study. | |
| | |
MedLine Citation:
|
PMID: 6391072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In a long-term multicenter open randomized study of 103 patients with glaucoma or intraocular hypertension, oral propranolol combined with 2% pilocarpine was compared with 0.5% topical timolol also combined with 2% pilocarpine, with respect to the effects on intraocular pressure and other signs of glaucoma. The results showed that the hypotensive effects were highly significant and equal for both treatments. There were no significant differences between the 2 groups in the amount of cupping of the nerve head or the visual field defects developing during treatment. An additive hypotensive effect was recorded when both propranolol and timolol were combined with pilocarpine, which indicates the development of tolerance to both beta-blockers. Pulse rate and blood pressure were moderately reduced in both groups, both significantly more so in the propranolol group. The investigation indicates that when combined with pilocarpine the 2 adrenergic beta-receptor blockers are equally effective. We believe that oral propranolol can improve drug compliance in the treatment of glaucoma. |
| | |
Authors:
|
A Ohrström; O Kättström; W Polland; J Mortensen; B Stenström |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Acta ophthalmologica Volume: 62 ISSN: 0001-639X ISO Abbreviation: Acta Ophthalmol (Copenh) Publication Date: 1984 Oct |
Date Detail:
|
Created Date: 1985-01-18 Completed Date: 1985-01-18 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370347 Medline TA: Acta Ophthalmol (Copenh) Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 681-95 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Clinical Trials as Topic Glaucoma / drug therapy* Glaucoma, Open-Angle / drug therapy* Hemodynamics / drug effects Humans Ophthalmic Solutions Pilocarpine / administration & dosage* Propranolol / administration & dosage*, adverse effects Random Allocation Timolol / administration & dosage*, adverse effects |
| Chemical | |
Reg. No./Substance:
|
0/Ophthalmic Solutions; 26839-75-8/Timolol; 525-66-6/Propranolol; 92-13-7/Pilocarpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Screening for detection of intra-uterine growth retardation by means of ultrasound.
Next Document: One- and two-session laser trabeculoplasty. A randomized, prospective study.