| Oral sustained delivery of paracetamol from in situ gelling xyloglucan formulations. | |
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MedLine Citation:
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PMID: 12648007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to evaluate the potential of a xyloglucan formulation with in situ gelling properties for the oral sustained delivery of paracetamol. Gelation of dilute aqueous solutions of the polysaccharide xyloglucan occurred in rabbit and rat stomachs as the orally administered chilled solutions attained body temperature. In vitro studies demonstrated diffusion-controlled release of paracetamol from the gels over a period of 6 hr. The bioavailabilities of paracetamol from the xyloglucan gels formed in situ in the stomachs of rabbits after oral administration of the liquid formulations were similar to that of a commercially available suspension containing an identical dose of paracetamol. |
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Authors:
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Shozo Miyazaki; Kumiko Endo; Naoko Kawasaki; Wataru Kubo; Hideki Watanabe; David Attwood |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Drug development and industrial pharmacy Volume: 29 ISSN: 0363-9045 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-03-21 Completed Date: 2003-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: United States |
Other Details:
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Languages: eng Pagination: 113-9 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Ishikari-Tohbetsu, Hokkaido, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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administration & dosage*,
chemistry*,
pharmacokinetics Administration, Oral Animals Biological Availability Chemistry, Pharmaceutical Delayed-Action Preparations Drug Carriers Drug Compounding Excipients / chemistry Gels Glucans* Male Pharmaceutical Solutions Polysaccharides / chemistry* Rabbits Rats Rats, Wistar Rheology Solubility Stomach / metabolism Suspensions Viscosity Xylans* |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 0/Drug Carriers; 0/Excipients; 0/Gels; 0/Glucans; 0/Pharmaceutical Solutions; 0/Polysaccharides; 0/Suspensions; 0/Xylans; 103-90-2/Acetaminophen; 37294-28-3/xyloglucan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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