Document Detail

Oral supplementation with physiological doses of leptin during lactation in rats improves insulin sensitivity and affects food preferences later in life.
MedLine Citation:
PMID:  17991728     Owner:  NLM     Status:  MEDLINE    
We have previously described that neonate rats supplemented with physiological doses of oral leptin during lactation become more protected against overweight in adulthood. The purpose of this study was to characterize further the long-term effects on glucose and leptin homeostasis and on food preferences. Neonate rats were supplemented during lactation with a daily oral dose of leptin or the vehicle. We followed body weight and food intake of animals until the age of 15 months, and measured glucose, insulin, and leptin levels under different feeding conditions: ad libitum feeding, 14-h fasting, and 3-h refeeding after fasting. An oral glucose tolerance test and a leptin resistance test were performed. Food preferences were also measured. Leptin-treated animals were found to have lower body weight in adulthood and to eat fewer calories than their controls. Plasma insulin levels were lower in leptin-treated animals than in their controls under the different feeding conditions, as was the increase in insulin levels after food intake. The homeostatic model assessment for insulin resistance index was significantly lower in leptin-treated animals, and the oral glucose tolerance test also indicated higher insulin sensitivity in leptin-treated animals. In addition, these animals displayed lower plasma leptin levels under the different feeding conditions and were also more responsive to exogenous leptin administration. Leptin-treated animals also showed a lower preference for fat-rich food than their controls. These observations indicate that animals supplemented with physiological doses of oral leptin during lactation were more protected against obesity and metabolic features of the metabolic syndrome.
Juana Sánchez; Teresa Priego; Mariona Palou; Aixa Tobaruela; Andreu Palou; Catalina Picó
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-08
Journal Detail:
Title:  Endocrinology     Volume:  149     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-22     Completed Date:  2008-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  733-40     Citation Subset:  AIM; IM    
Laboratorio de Biología Molecular, Nutrición y Biotecnología (Nutrigenómica), Universidad de las Islas Baleares, 07122, Palma de Mallorca, Spain.
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MeSH Terms
Administration, Oral
Animals, Newborn
Animals, Suckling
Blood Glucose / metabolism
Body Weight / drug effects,  physiology
Food Preferences / physiology*
Glucose Intolerance / physiopathology,  prevention & control*
Glucose Tolerance Test
Homeostasis / drug effects,  physiology
Insulin Resistance*
Lactation / physiology
Leptin / blood,  pharmacology*
Obesity / physiopathology,  prevention & control*
Rats, Wistar
Reg. No./Substance:
0/Blood Glucose; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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