Document Detail

Oral submucous fibrosis, a clinically benign but potentially malignant disease: report of 3 cases and review of the literature.
MedLine Citation:
PMID:  18845065     Owner:  NLM     Status:  MEDLINE    
Oral submucous fibrosis (OSF) is a premalignant condition mainly associated with the practice of chewing betel quid containing areca nut, a habit common among South Asian people. It is characterized by inflammation, increased deposition of submucosal collagen and formation of fibrotic bands in the oral and paraoral tissues, which increasingly limit mouth opening. Recently, OSF has been reported among South Asian immigrants in Canada, the United Kingdom and Germany. Dentists in western countries should enhance their knowledge of this disease as it seems to be increasing with population migration. In this paper, we review the literature on OSF and present 3 cases representing different stages of the disease to help dentists make an early diagnosis and reduce the morbidity and mortality associated with this condition.
Ajit Auluck; Miriam P Rosin; Lewei Zhang; K N Sumanth
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal (Canadian Dental Association)     Volume:  74     ISSN:  1488-2159     ISO Abbreviation:  J Can Dent Assoc     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-10     Completed Date:  2009-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7907605     Medline TA:  J Can Dent Assoc     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  735-40     Citation Subset:  D; IM    
Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia.
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MeSH Terms
Areca / adverse effects
Carcinoma, Squamous Cell / pathology
Cell Transformation, Neoplastic
Collagen / metabolism
Disease Progression
Gingival Neoplasms / pathology
Glucocorticoids / administration & dosage
Injections, Intralesional
Middle Aged
Oral Submucous Fibrosis / drug therapy,  etiology,  pathology*
Precancerous Conditions / pathology
Young Adult
Reg. No./Substance:
0/Glucocorticoids; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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