| Oral subchronic toxicity of aqueous crude extract of Plantago australis leaves. | |
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MedLine Citation:
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PMID: 12902047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The toxic effects of chronic oral administration (60 days) of aqueous crude extract (AE) of Plantago australis Lam. (Plantaginaceae) in rats at doses of 850 and 1700 mg/kg on biochemical (ALT, AST, creatinine, urea, glucose, alkaline phosphatase, total proteins and albumin), hematological (complete hemogram), and histopathological (heart, lung, liver, kidney, esophagus, stomach and gut) parameters were studied. All biochemical and hematological parameters were found to be in the normal range, but ALT in animals that received AE of 850 mg/kg was higher. Histopathological analysis of organs, especially the liver did not present alterations. |
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Authors:
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N M S Palmeiro; C E Almeida; P C Ghedini; L S Goulart; M C F Pereira; S Huber; J E P da Silva; S Lopes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 88 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-06 Completed Date: 2004-01-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 15-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Federal University of Santa Maria, RS 97105-900, Santa Maria, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral* Alanine Transaminase / blood, drug effects Animals Blood / drug effects Brazil Complex Mixtures / administration & dosage, toxicity* Female Lung / drug effects, pathology Male Plant Extracts / administration & dosage, toxicity Plant Leaves / chemistry, toxicity* Plantago / chemistry, toxicity* Rats Rats, Wistar Sex Factors Toxicity Tests / methods* |
| Chemical | |
Reg. No./Substance:
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0/Complex Mixtures; 0/Plant Extracts; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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