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Oral simvastatin reduces the hypertensive response to air-jet stress.
MedLine Citation:
PMID:  22233179     Owner:  NLM     Status:  Publisher    
1. Brain angiotensin II and vasopressin play important roles in the neurogenic regulation of the circulatory system, for example in cardiovascular responses to stress. Recently, it has become evident that the positive effects of statins are not limited to their lipid lowering properties, for example it has been found that statins interact with angiotensin peptides. 2. In this study we tested the hypothesis that simvastatin affects hemodynamic responses to air-jet stress and intracerebroventricular infusions of vasopressin and angiotensin II. We maintained 12-week-old, male, Sprague Dawley rats either on tap water (control) or on water containing simvastatin 20mg/L, 40mg/L or 60mg/L for four weeks. Subsequently, we measured arterial blood pressure and heart rate at baseline and after air-jet stress, or intracerebroventricular infusions of angiotensin II or vasopressin or their antagonists. 3. We found no significant difference between the control group and simvastatin groups in baseline mean arterial blood pressure and heart rate. In rats given simvastatin 60mg/L, the hypertensive response to air-jet stress was significantly smaller than in controls as was the increase in mean arterial blood pressure in response to angiotensin II. In contrast, there was no significant difference between the groups in the hypertensive response to vasopressin. 4. These findings show that simvastatin affects the hypertensive response to air-jet stress and provide evidence that statins may affect the brain regulation of the circulatory system. © 2012 The Authors Clinical and Experimental Pharmacology and Physiology© 2012 Blackwell Publishing Asia Pty Ltd.
Marcin Ufnal; Adrian Drapala; Mariusz Sikora; Ewa Szczepanska-Sadowska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-10
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  -     ISSN:  1440-1681     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Clinical and Experimental Pharmacology and Physiology © 2012 Blackwell Publishing Asia Pty Ltd.
Department of Experimental and Clinical Physiology, Medical University of Warsaw, 00-927 Warsaw, Krakowskie Przedmiescie 26/28, Poland.
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