| Oral scopolamine augmentation in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled study. | |
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MedLine Citation:
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PMID: 23146150 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the antidepressant effect of oral scopolamine as an adjunct to citalopram. METHOD: In this randomized double-blind placebo-controlled study, patients were assessed in the outpatient clinics of 2 large hospitals from November 2011 to January 2012. Forty patients (18-55 years) with major depressive disorder (DSM-IV-TR criteria) and 17-Item Hamilton Depression Rating Scale (HDRS) score ≥ 22 were randomly assigned to scopolamine hydrobromide (1 mg/d) (n = 20) or placebo (n = 20) in addition to citalopram for 6 weeks. HDRS score was measured at baseline and days 4, 7, 14, 28, and 42. The primary outcome measure was HDRS score change from baseline to week 6 in the scopolamine group versus the placebo group. Response was defined as ≥ 50% decrease in HDRS score; remission, as HDRS score ≤ 7. RESULTS: Augmentation with scopolamine was significantly more effective than placebo (F1,38 = 5.831, P = .021). Patients receiving scopolamine showed higher rates of response (65%, 13/20 at week 4) and remission (65%, 13/20 at week 6) than the placebo group (30%, 6/20 and 20%, 4/20, respectively; P = .027, P = .004, respectively). Patients in the scopolamine group showed higher rates of dry mouth, blurred vision, and dizziness than the placebo group. CONCLUSIONS: Oral scopolamine is a safe and effective adjunct for treatment of patients with moderate to severe major depressive disorder. TRIAL REGISTRATION: Iranian Registry of Clinical Trials identifier: IRCT201201181556N31. |
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Authors:
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Danial Khajavi; Mehdi Farokhnia; Amirhossein Modabbernia; Mandana Ashrafi; Seyed-Hesammedin Abbasi; Mina Tabrizi; Shahin Akhondzadeh |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-16 |
Journal Detail:
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Title: The Journal of clinical psychiatry Volume: - ISSN: 1555-2101 ISO Abbreviation: J Clin Psychiatry Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7801243 Medline TA: J Clin Psychiatry Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Copyright 2012 Physicians Postgraduate Press, Inc. |
Affiliation:
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Psychiatric Research Centre, Roozbeh Hospital, Tehran, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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