Document Detail


Oral progestogen versus intramuscular progesterone for luteal support after assisted reproductive technology treatment: a prospective randomized study.
MedLine Citation:
PMID:  17938943     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the efficacy of oral progestogen, chlormadinone acetate, and intramuscular (IM) progesterone for luteal support in patients, undergoing assisted reproductive technology (ART) treatment, who were treated with a gonadotropin-releasing hormone agonist (GnRHa). METHODS: This was a prospective randomized study of 40 patients with normal and high response (serum estradiol > 2,000 pg/ml) in GnRHa down-regulation. Patients were randomized to receive either oral chlormadinone acetate or IM progesterone. The outcomes of ART treatment, including pregnancy and embryo implantation rates, were analyzed. RESULTS: There were no significant differences in the clinical pregnancy rates (25 vs. 20%) and in the implantation rates (12.7 vs. 9.1%) of patients who received IM progesterone and oral chlormadinone acetate. Endometrial thickness was also comparable between oral chlormadinone acetate and IM progesterone. CONCLUSION: Oral progestogen, chlormadinone acetate showed a comparable pregnancy rate and live birth rate with IM progesterone as luteal support for the high responders. The optimal methods for luteal support may be dependent on responses to stimulation with gonadotropin, although it is not concluded that oral chlormadinone acetate is recommended as an option for luteal support in high responders.
Authors:
Akira Iwase; Hisao Ando; Shigeru Toda; Shino Ishimatsu; Toko Harata; Shozo Kurotsuchi; Yuji Shimomura; Maki Goto; Fumitaka Kikkawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2007-10-16
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  277     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-09-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  319-24     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan. akiwase@med.nagoya-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Androgen Antagonists / administration & dosage*,  therapeutic use
Chlormadinone Acetate / administration & dosage*,  therapeutic use
Down-Regulation
Embryo Implantation
Female
Gonadotropin-Releasing Hormone / agonists
Gonadotropins / administration & dosage*
Humans
Injections, Intramuscular
Luteal Phase / drug effects*
Luteinizing Hormone
Luteolytic Agents / administration & dosage*,  adverse effects
Pregnancy
Pregnancy Outcome
Progesterone / administration & dosage*,  blood,  therapeutic use
Prospective Studies
Reproductive Techniques, Assisted*
Chemical
Reg. No./Substance:
0/Androgen Antagonists; 0/Gonadotropins; 0/Luteolytic Agents; 302-22-7/Chlormadinone Acetate; 33515-09-2/Gonadotropin-Releasing Hormone; 57-83-0/Progesterone; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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