| Oral plasmablastic lymphoma in an HIV-negative patient: a case report and review of the literature. | |
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MedLine Citation:
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PMID: 16037778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasmablastic lymphoma is an HIV-associated non-Hodgkin's lymphoma that primarily affects the oral cavity and jaws. The purpose of this report is to describe the first case of plasmablastic lymphoma occurring in an HIV-negative, nonimmunocompromised individual, and to review the histopathologic and immunohistochemical phenotype of this lymphoma. Histopathologically, our case exhibited a dense, diffuse lymphocytic infiltrate of noncohesive large lymphocytes with plasmacytoid features. Immunohistochemical analysis revealed positivity for the B-cell marker CD79a, VS38c, Epstein-Barr virus latent membrane protein (LMP), immunoglobulin G (IgG), and lambda light chain restriction. Neoplastic cells were negative for leukocyte common antigen, CD20, CD3, CD10, CD138, Bcl-2, Bcl-6, desmin, actin, EMA, S-100, HMB45, Alk-1, HHV8, IgA, IgM, and cytokeratin. The features of this rare disease are summarized based on a comprehensive review of the epidemiologic, clinical and immunohistochemical findings of previously reported cases. |
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Authors:
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Mark A Scheper; Nikolaos G Nikitakis; Rui Fernandes; Christopher D Gocke; Robert A Ord; John J Sauk |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 100 ISSN: 1528-395X ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-07-22 Completed Date: 2006-02-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: 198-206 Citation Subset: D; IM |
Affiliation:
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Department of Diagnostic Sciences and Pathology, University of Maryland Dental School, Baltimore, MD 21201, USA. mas003@dental.umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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HIV Seronegativity Humans Immunoglobulin G / analysis Immunoglobulin lambda-Chains / analysis Immunohistochemistry Lymphoma, B-Cell / pathology* Lymphoma, Large B-Cell, Diffuse / pathology* Male Mandibular Neoplasms / pathology* Middle Aged Plasma Cells Viral Matrix Proteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/EBV-associated membrane antigen, Epstein-Barr virus; 0/Immunoglobulin G; 0/Immunoglobulin lambda-Chains; 0/Viral Matrix Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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