Document Detail

Oral phenobarbital given antenatally to reduce neonatal intraventricular hemorrhage. A comparison between maternal and umbilical cord serum levels at delivery.
MedLine Citation:
PMID:  2809779     Owner:  NLM     Status:  MEDLINE    
This investigation was undertaken to compare maternal and neonatal cord serum levels of phenobarbital given orally to mothers anticipated to deliver very low birthweight infants at risk for neonatal intraventricular hemorrhage (IVH). Fifty women anticipated to deliver between 26 and 34 weeks' gestation agreed to receive a daily oral dose of 90 mg of phenobarbital. The umbilical cord to maternal phenobarbital concentration ratio at birth was 1.05 and remained constant after the first day of maternal therapy. Cord phenobarbital concentrations increased rapidly during the first 3 days until reaching a steady state by the end of the first week of therapy. In contrast to recent promising reports using large doses of phenobarbital given parenterally shortly before delivery, lower doses of oral phenobarbital did not reach cord levels reported to be protective against IVH or therapeutic as an anticonvulsant.
W Rayburn; S Donn; A Compton; E Piehl
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  9     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-11-30     Completed Date:  1989-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  268-70     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Nebraska Medical Center, Omaha 68105.
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MeSH Terms
Administration, Oral
Cerebral Hemorrhage / prevention & control*
Fetal Blood / analysis*
Infant, Newborn
Labor, Obstetric / blood*
Phenobarbital / administration & dosage,  blood*,  therapeutic use
Prenatal Exposure Delayed Effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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