Document Detail


Oral passive IgY-based immunotherapeutics: a novel solution for prevention and treatment of alimentary tract diseases.
MedLine Citation:
PMID:  23319156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This commentary summarizes the laboratory investigations and clinical trials published recently involving per-oral application of IgY supplemented food for specific orogastrointestinal disease prevention and control purposes. The prolonged use and misuse of conventional antibacterial drugs has spawned antibiotic resistant microbes prompting scientists to search for other germ-killing options. In particular, the use of IgY as a novel mode of immunotherapy using oral chicken immunoglobulin (IgY) to confer passive immunity has gained much interest as an inexpensive non-antibiotic alternative for the prophylaxis and treatment of a wide variety of infectious diseases. The stability of IgY in the orogastrointestinal tract and its safety profile has been well-documented. IgY has been used in the treatment or prevention of dental caries, periodontitis and gingivitis, gastritis and gastric ulcer, oral thrush and infant rotavirus diarrhea. The recent clinical trials on IgY with encouraging results has catapulted into the market novel nutraceutical or health supplements for therapeutic or prophylactic intervention based on the consumption of mono-specific or mixed IgY formulations. With recent trends in consumer preference for natural materials to alleviate health concerns, the increasing healthcare costs and the recent advances in drug delivery systems, IgY is likely to shift from its mainly functional food status toward pharmaceuticalization in the foreseeable future.
Authors:
Shofiqur Rahman; Sa Van Nguyen; Faustino C Icatlo; Kouji Umeda; Yoshikatsu Kodama
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-14
Journal Detail:
Title:  Human vaccines & immunotherapeutics     Volume:  9     ISSN:  2164-554X     ISO Abbreviation:  Hum Vaccin Immunother     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-10-07     Completed Date:  2014-05-05     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  101572652     Medline TA:  Hum Vaccin Immunother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1039-48     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Clinical Trials as Topic
Communicable Diseases / therapy*
Digestive System Diseases / prevention & control*,  therapy*
Drug Evaluation, Preclinical
Humans
Immunization, Passive / methods*
Immunoglobulins / administration & dosage*,  immunology
Immunologic Factors / administration & dosage*,  immunology
Chemical
Reg. No./Substance:
0/IgY; 0/Immunoglobulins; 0/Immunologic Factors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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