Document Detail

Oral mucous membrane lesions in children treated with bone marrow transplantation.
MedLine Citation:
PMID:  2662386     Owner:  NLM     Status:  MEDLINE    
Oral mucous membrane lesions were studied in 54 children below 12 yr of age treated with allogeneic bone marrow transplantation mainly because of hematological malignancies. Sixty-two percent of the children exhibited a wide range of oral side effects during therapy. Lesions observed during the first 2 wk prior to engraftment of the donor marrow were related to the chemo- and radiotherapy given. Oral ulcerations were seen in 34% of the children. Children given methotrexate as graft-versus-host disease (GVHD) prophylaxis exhibited oral ulcerations significantly (P less than 0.05) more often than those given cyclosporin. Oral lesions related to acute GVHD were only observed in two patients. Reactivating herpes simplex virus infection was seen in 35% of the children who were seropositive prior to BMT. An extensive oral candidiasis was observed in 15% of the patients. All six children with a chronic GVHD exhibited changes in the oral mucosa 2-4 yr after transplantation such as erythma of the mucous membranes, tongue atrophy and also lichenoid changes in the buccal mucosa.
G Dahllöf; A Heimdahl; T Modéer; S Twetman; P Bolme; O Ringdén
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of dental research     Volume:  97     ISSN:  0029-845X     ISO Abbreviation:  Scand J Dent Res     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-07-28     Completed Date:  1989-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0270023     Medline TA:  Scand J Dent Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  268-77     Citation Subset:  D; IM    
Department of Pedodontics, School of Dentistry, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Bone Marrow Transplantation*
Child, Preschool
Follow-Up Studies
Graft vs Host Disease / complications
Herpes Simplex
Immunosuppression / adverse effects*
Mouth Diseases / etiology*,  therapy
Mouth Mucosa / pathology*
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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