| Oral mucosal fixed drug eruption: Characteristics and differential diagnosis. | |
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MedLine Citation:
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PMID: 23044075 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Little is known about the characteristic features of oral mucosal fixed drug eruption (FDE). OBJECTIVE: To present the clinical highlights and the differential diagnosis of oral mucosal FDE in a relatively large group of patients from Turkey. METHODS: This was a methodological, retrospective, cross-sectional study of 61 patients with oral mucosal FDE. The causative drug was established mainly by oral provocation test. RESULTS: The age range of 61 patients (38 females, 23 males) was 7 to 62 years. Naproxen and cotrimoxazole were the main inducers. Fourteen patients (23%) had a solitary oral lesion predominantly located on the dorsum of the tongue, or on the hard palate, the former statistically significantly associated with cotrimoxazole. Bullous/erosive (n = 47), aphthous (n = 12), and erythematous (n = 2) morphology were observed. A considerable number of patients were referred with a prior clinical diagnosis of herpes simplex and Behçet's disease; some of them were already receiving long-term treatment with acyclovir and colchicine, respectively. LIMITATIONS: The main limitation of the present study resides in its retrospective design. CONCLUSIONS: Isolated oral lesions, aphthous lesions, severe bullous/erosive lesions, and the absence of residual pigmentation are the main features that may cause difficulties in the differential diagnosis. It is important to differentiate dysmenorrhea-related monthly attacks of oral FDE in female patients caused by nonsteroidal anti-inflammatory drugs from menstruation-triggered attacks of herpes simplex infection, and isolated orogenital aphthous FDE from Behçet's disease, especially in countries with a high frequency of the disease in order to prevent irrelevant therapies. |
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Authors:
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Esen Ozkaya |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-5 |
Journal Detail:
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Title: Journal of the American Academy of Dermatology Volume: - ISSN: 1097-6787 ISO Abbreviation: J. Am. Acad. Dermatol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7907132 Medline TA: J Am Acad Dermatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Department of Dermatology and Venereology, Istanbul University, İstanbul Medical Faculty, Istanbul, Turkey. Electronic address: profeo@istanbul.edu.tr. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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