| Oral, more than transdermal, estrogen therapy improves lipids and lipoprotein(a) in postmenopausal women: a randomized, placebo-controlled study. | |
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MedLine Citation:
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PMID: 14627865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the effects of low-dose oral and transdermal estrogen therapy on the lipid profile and lipoprotein(a) [Lp(a)] levels in healthy, postmenopausal women and to study the additional influence of gestodene administration. DESIGN: In a multicenter, randomized, double-blind, placebo-controlled study, 152 healthy, hysterectomized, postmenopausal women received daily either placebo (n = 49), 50 microg transdermal 17beta-estradiol (tE2, n = 33), 1 mg oral 17beta-estradiol (oE2, n = 37), or 1 mg oE2 combined with 25 microg gestodene (oE2 + G, n = 33) for 13 cycles of 28 days, followed by 4 cycles of placebo in each group. Fasting serum concentrations of total, high-density lipoprotein (HDL) cholesterol and low-density lipoprotein (LDL) cholesterol, triglycerides, and Lp(a) were measured at baseline and in cycles 4, 13, and 17. RESULTS: In cycle 13, a significant mean percentage decrease from baseline was found in all treatment groups compared with placebo in total cholesterol (tE2, -4.7%; oE2, -6.9%; oE2 + G, -10.5%) and LDL cholesterol (tE2, -5.8%; oE2, -12.6%; oE2 + G, -13.6%). For both oral groups, the reductions were already significant in cycle 4. None of the treatment groups showed a significant change in HDL cholesterol or triglycerides. In cycle 13, Lp(a) was decreased compared with placebo in the oE2 group (-6.6%) and the oE2 + G group (-8.2%). After washout, all observed changes had returned to baseline level, except for the decreases in total and LDL cholesterol in the oE2 + G group. CONCLUSIONS: Oral E2 and E2 + G, and to a lesser extent transdermal E2, decreased total and LDL cholesterol. Lp(a) was lowered only by the oral treatments. |
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Authors:
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Majoie Hemelaar; Marius J van der Mooren; Velja Mijatovic; Anneke A Bouman; Charles P T Schijf; Maurice V A M Kroeks; Henk R Franke; Peter Kenemans |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 10 ISSN: 1072-3714 ISO Abbreviation: Menopause Publication Date: 2003 Nov-Dec |
Date Detail:
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Created Date: 2003-11-20 Completed Date: 2004-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 550-8 Citation Subset: IM |
Affiliation:
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Project Ageing Women and the Institute for Cardiovascular Research, the Department of Obstetrics & Gynecology, VU Medical Center, Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Administration, Oral Double-Blind Method Estradiol / administration & dosage* Estrogen Replacement Therapy / methods* Female Humans Lipids / blood* Lipoprotein(a) / blood, drug effects* Middle Aged Norpregnenes / administration & dosage* Placebo Effect Postmenopause / blood* Progestins / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Lipoprotein(a); 0/Norpregnenes; 0/Progestins; 50-28-2/Estradiol; 60282-87-3/Gestodene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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