Document Detail

Oral misoprostol for premature rupture of membranes at term.
MedLine Citation:
PMID:  14526301     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The study was undertaken to compare the efficacy, safety, and maternal satisfaction of oral misoprostol and intravenous oxytocin for labor induction in women with premature rupture of membranes at term. STUDY DESIGN: One hundred five women were stratified by parity and randomly assigned to oral misoprostol 75 microg every 4 hours as needed to establish labor or to intravenous oxytocin. RESULTS: The induction to vaginal delivery time with oral misoprostol was 737 (+/-426) minutes compared with 573 (+/-318) minutes with oxytocin (P=.04). The incidence of hyperstimulation was lower in the misoprostol group (6.0% vs 27.1%, P=.005). Women were more likely to be very satisfied with their care in the misoprostol group (86.0% vs 63.4%, P=.02). CONCLUSION: In women at term with premature rupture of membranes, oral misoprostol resulted in a longer induction to vaginal delivery interval but increased maternal satisfaction and less hyperstimulation compared with intravenous oxytocin. Further research is needed to assess uncommon neonatal and maternal outcomes.
Joan M G Crane; Tina Delaney; Donna Hutchens
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  189     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-03     Completed Date:  2003-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-4     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Memorial University of Newfoundland, St. John's, Canada.
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MeSH Terms
Fetal Membranes, Premature Rupture*
Labor, Induced / methods*
Logistic Models
Misoprostol / administration & dosage*,  adverse effects
Oxytocics / administration & dosage*
Oxytocin / administration & dosage
Patient Satisfaction
Time Factors
Reg. No./Substance:
0/Oxytocics; 50-56-6/Oxytocin; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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