Document Detail

Oral misoprostol for induction of labour.
MedLine Citation:
PMID:  20378037     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To determine the effect of oral Misoprostol in labour induction with respect to ease of administration and induction-to-delivery time interval.
STUDY DESIGN: Observational study.
PLACE AND DURATION OF STUDY: Gynaecology/Obstetrics Department, Holy Family Hospital, Rawalpindi, from March to August 2006.
METHODOLOGY: Women with live singleton pregnancy of > 37 weeks gestation with cephalic presentation, with an indication for induction of labour were inducted. Oral misoprostol 50 microg to 400 microg was given in divided doses at 4 hours interval upto a maximum of 4 doses, till labour was induced. Fetomaternal outcome and induction to delivering time interval in hours was noted.
RESULTS: In 6 months duration, 250 mothers were recruited for the study. The main indication for labour induction was post date pregnancy (52%) and oxytocin was given in 50% cases. The majority (96%) of mothers went into labour but 4% (9) had failed induction. The majority (73%, n=176/241) of mothers delivered vaginally, 99% being delivered in the first 24 hours. Mean induction-delivery interval was 11+/-2.7 hours. Sixty five (27%) had to undergo emergency lower segment caesarean section, the major indication being fetal distress (41.5%, n=27) and meconium staining of liquor (40%, n=26). Again, a majority (95%) of the babies were delivered with good Apgar score. However, 10.8% developed meconium aspiration syndrome. Early neonatal deaths occurred in 0.8% (2) cases. Maternal hyper stimulation was seen in 1 case (0.4%).
CONCLUSION: Oral misoprostol as an agent for labour induction in term pregnancy was easy to administer and the majority of women (99%) delivered in the first 24 hours.
Shazia Syed; Rizwana Chaudhri; Farwa Rizvi; Muhammad Afzal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP     Volume:  20     ISSN:  1022-386X     ISO Abbreviation:  J Coll Physicians Surg Pak     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-04-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606447     Medline TA:  J Coll Physicians Surg Pak     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  102-5     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Holy Family Hospital, Rawalpindi.
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