Document Detail

Oral misoprostol administration for labor induction.
MedLine Citation:
PMID:  16885670     Owner:  NLM     Status:  MEDLINE    
Using oral agents for induction of labor would reduce the need for repeated vaginal examinations; this is more acceptable to women and could reduce infection rates. A systematic review was conducted of 41 randomized trials comparing oral misoprostol to other induction agents. Oral misoprostol is effective at achieving vaginal delivery, and may have benefits over both vaginal and intracervical dinoprostone. Although it does not achieve vaginal delivery as quickly as vaginal misoprostol, the rates of hyperstimulation are lower when using comparable doses. As the primary consideration should be safety rather than speed, an oral regimen using a maximum of 50 mcg 4 hourly is recommended.
Andrew Weeks; Zarko Alfirevic
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical obstetrics and gynecology     Volume:  49     ISSN:  0009-9201     ISO Abbreviation:  Clin Obstet Gynecol     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-03     Completed Date:  2006-10-27     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0070014     Medline TA:  Clin Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  658-71     Citation Subset:  IM    
School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool Women's Hospital, Liverpool, UK.
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MeSH Terms
Administration, Oral
Labor, Induced / methods*
Misoprostol / pharmacokinetics,  therapeutic use*
Oxytocics / pharmacokinetics,  therapeutic use*
Reg. No./Substance:
0/Oxytocics; 59122-46-2/Misoprostol

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